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Titolo:
Determinants of the severity and extent of coronary artery disease in patients with type-2 diabetes and in nondiabetic subjects
Autore:
Syvanne, M; Pajunen, P; Kahri, J; Lahdenpera, S; Ehnholm, C; Nieminen, MS; Taskinen, MR;
Indirizzi:
Univ Helsinki, Cent Hosp, Div Cardiol, Dept Med, FIN-00029 Hyks, Finland Univ Helsinki Hyks Finland FIN-00029 , Dept Med, FIN-00029 Hyks, Finland Univ Helsinki, Cent Hosp, Dept Med, Div Cardiol, Helsinki, Finland Univ Helsinki Helsinki Finland Dept Med, Div Cardiol, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Med, Div Endocrinol & Diabet, Helsinki, Finland Univ Helsinki Helsinki Finland v Endocrinol & Diabet, Helsinki, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 2, volume: 12, anno: 2001,
pagine: 99 - 106
SICI:
0954-6928(200103)12:2<99:DOTSAE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
11-YEAR FOLLOW-UP; HEART-DISEASE; RISK-FACTORS; MYOCARDIAL-INFARCTION; CARDIOVASCULAR MORTALITY; ATHEROSCLEROSIS; LIPOPROTEINS; MELLITUS; MEN; APOLIPOPROTEINS;
Keywords:
coronary artery disease; coronary angiography; diabetes; vascular risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Syvanne, M Univ Helsinki, Cent Hosp, Div Cardiol, Dept Med, POB 340, FIN-00029 Hyks, Finland Univ Helsinki POB 340 Hyks Finland FIN-00029 029 Hyks, Finland
Citazione:
M. Syvanne et al., "Determinants of the severity and extent of coronary artery disease in patients with type-2 diabetes and in nondiabetic subjects", CORON ART D, 12(2), 2001, pp. 99-106

Abstract

Background factors predicting the anatomic distribution and the severity and extent of coronary atherosclerosis in patients with clinically manifest coronary artery disease (CAD) for type-2 diabetic patients could be different than those for nondiabetic patients. Objective To study the determinants of severity and extent of CAD in consecutive patients with type 2 diabetes mellitus, compared with those for matched nondiabetic patients, undergoing clinically indicated coronary angiography. Methods Coronary angiograms of 48 men and seven women with type-2 diabetesand an equal number of nondiabetic subjects were analyzed quantitatively. Scores reflecting severity and extent of CAD were compared with potential risk factors using univariate correlation analyses and multivariate regression models. Results For the diabetics, a global coronary atheroma burden index was independently and directly related to age (P = 0.022) and to level of intermediate-density lipoprotein cholesterol (P = 0.055), and inversely to level ofparticles of a subtype of high-density lipoprotein (P = 0.022), Several angiographic indexes were related to the duration of diabetes and control of glycemia. For the nondiabetic group, global atheroma burden was independently related to age (P = 0.028), a history of hypertension (P = 0.028), and concentration of low-density lipoprotein (P = 0.013), and inversely to levelof apolipoprotein A-I (P = 0.008). The duration of coronary disease and a history of smoking were also predictive of severe coronary atherosclerosis among nondiabetic patients,Conclusions Classical risk factors are strong predictors of the severity and extent of coronary atherosclerosis in nondiabetic patients, but the mostimportant determinants for type-2 diabetic patients are levels of triglyceride-rich lipoproteins and apolipoprotein A-I-containing particles of high-density lipoprotein, and factors directly related to diabetes. Coron ArteryDis 12:99-106 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 04:07:23