Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
New nephron development in goldfish (Carassius auratus) kidneys following repeated gentamicin-induced nephrotoxicosis
Autore:
Salice, CJ; Rokous, JS; Kane, AS; Reimschuessel, R;
Indirizzi:
US FDA, Ctr Vet Med, Res Off, Laurel, MD 20708 USA US FDA Laurel MD USA 20708 DA, Ctr Vet Med, Res Off, Laurel, MD 20708 USA
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 1, volume: 51, anno: 2001,
pagine: 56 - 59
SICI:
1532-0820(200102)51:1<56:NNDIG
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXACHLOROBUTADIENE; REGENERATION; LIGHT; FISH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Reimschuessel, R US FDA, Ctr Vet Med, Res Off, 8401 Muirkirk Rd, Laurel, MD 20708 USA US FDA 8401 Muirkirk Rd Laurel MD USA 20708 MD 20708 USA
Citazione:
C.J. Salice et al., "New nephron development in goldfish (Carassius auratus) kidneys following repeated gentamicin-induced nephrotoxicosis", COMPAR MED, 51(1), 2001, pp. 56-59

Abstract

Renal development in mammalian kidneys can only be studied in embryonic animals. Hence, research in this area is hampered by the need to maintain pregnant animals and by the small size of the embryonic kidney. Here, we describe a goldfish (Carassius auratus) model for studying renal repair and nephron development in an adult animal. Previous studies have indicated that chemically induced nephrotoxicosis in goldfish is followed by new nephron development. We tested the hypothesis that new nephron development is not a one-time only event and, thus, will occur after repeated nephrotoxic events. We used repeated injections of gentamicin (50 mg/kg of body weight), a nephrotoxic antibiotic, which has been used as a model nephrotoxicant to study renal repair. Fish were allowed either a recovery period of 9 or 24 weeks between injections. In both experiments, new nephrons developed after each injection of gentamicin, supporting our hypothesis. Nephron development occurring after a 9-week recovery period was similar to development observed after a 24-week recovery period; therefore, the shorter experimental paradigmappears sufficient and can save time and money. Future research using thisfish nephrogenesis model may identify the genes responsible for nephron neogenesis, Such information is a prerequisite for developing alternative renal replacement therapies based on the induction of de novo nephrogenesis indiseased kidneys.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:29:01