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Titolo:
The effect of hydrogen peroxide on isolated body wall of the lugworm Arenicola marina (L.) at different extracellular pH levels
Autore:
Storch, D; Abele, D; Portner, HO;
Indirizzi:
Alfred Wegener Inst Polar & Meeresforsch, D-27568 Bremerhaven, Germany Alfred Wegener Inst Polar & Meeresforsch Bremerhaven Germany D-27568 any
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 3, volume: 128, anno: 2001,
pagine: 391 - 399
SICI:
1532-0456(200103)128:3<391:TEOHPO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR PH; ENVIRONMENTAL-STRESS; LIPID-PEROXIDATION; OXIDATIVE STRESS; FREE-RADICALS; MECHANISMS; INJURY; PHOSPHORYLATION; TEMPERATURES; POLYCHAETA;
Keywords:
Arenicola marina; acid-base status; extracellular pH; hydrogen peroxide; intracellular acidification; intracellular pH; isolated body wall tissue; malondialdehyde; metabolic depression; oxygen consumption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Storch, D Alfred Wegener Inst Polar & Meeresforsch, Columbusstr, D-27568 Bremerhaven, Germany Alfred Wegener Inst Polar & Meeresforsch Columbusstr Bremerhaven Germany D-27568
Citazione:
D. Storch et al., "The effect of hydrogen peroxide on isolated body wall of the lugworm Arenicola marina (L.) at different extracellular pH levels", COMP BIOC C, 128(3), 2001, pp. 391-399

Abstract

The effect of hydrogen peroxide on the rate of tissue oxygen consumption, on intracellular pH (pH,) and on malondialdehyde (MDA) accumulation was studied in isolated body wall tissue of the lugworm Arenicola marina (L.). H2O2 effects were investigated at various levels of pH(i) by changing medium pH (pH(e)). The largest decrease of tissue oxygen consumption (by 17% below controls), as well as the highest degree of MDA accumulation (four-fold compared to control values) after H2O2 exposure were found at acidic pH(e) of 6.4. This was attributed to the higher redox potential of H2O2 in acidic solutions. Oxygen consumption at alkaline pH(e) (8.5) was not affected by H2O2. MDA accumulation in the tissue was considerably lower than at pH(e), 7.4or 6.4. Despite pH dependent alterations of H2O2 redox potential, we observed more or less constant pH, independent acidification of the tissue upon exposure to H2O2. We attributed the acidification to an inhibition of ATP consuming proton equivalent ion transport across the cellular membrane. Inactivation of carrier proteins is discussed to be responsible for the decrease in tissue oxygen consumption. However, with a larger effect on oxygen consumption at acidic pH, values, the latter may not be the only explanation, but additional impairment of other energy demanding processes may be involved. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:46:19