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Titolo:
Expression of metallothionein in the liver and kidney of rats is influenced by excess dietary histidine
Autore:
Aoyama, Y; Kato, C; Sakakibara, S;
Indirizzi:
Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608599, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608599 oro, Hokkaido 0608599, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 3, volume: 128, anno: 2001,
pagine: 339 - 347
SICI:
1532-0456(200103)128:3<339:EOMITL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ZINC-DEFICIENCY; GENE-EXPRESSION; LIPIDS; METABOLISM; INDUCTION; COPPER;
Keywords:
histidine; metallothionein; ceruloplasmin; copper; zinc; liver; kidney; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Aoyama, Y Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Kita Ku, Nishi 9,Kita 9, Sapporo, Hokkaido 0608599, Japan Hokkaido Univ Nishi 9,Kita 9 Sapporo Hokkaido Japan 0608599 apan
Citazione:
Y. Aoyama et al., "Expression of metallothionein in the liver and kidney of rats is influenced by excess dietary histidine", COMP BIOC C, 128(3), 2001, pp. 339-347

Abstract

It is well known that excess dietary histidine induces the metabolic changes in copper and zinc. Therefore, this study was carried out to clarify whether excess dietary histidine alters the gene expressions of metallothionein-l and metallothionein-2 in the liver and kidney. Male rats were fed the control (ad libitum and pair-fed) or histidine-excess (50 g of (L)-histidineper kg of diet) diet for 0, 1 and 3 days. The levels of liver metallothionein-1 and metallothionein-2 mRNA were markedly lower in the rats fed the histidine-excess diet as compared to those of the control (ad libitum and pair-fed) diet, when fed for 1 or 3 days. The levels of renal metallothionein-1 and metallothionein-2 mRNA in the rats fed the histidine-excess diet werehigher or tended to be higher as compared with the rats fed the control (ad libitum and pair-fed) diet when fed for 1 or 3 days, respectively. At the: same time, hepatic copper content was decreased and renal zinc content was increased by dietary histidine. It thus appears, that such a response on the level of liver metallothionein mRNA might be related to the contents: of liver copper, but of kidney metallothionein mRNA might be due to the content of zinc. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:54:12