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Titolo:
Occupational exposure to volatile anaesthetics - Epidemiology and approaches to reducing the problem
Autore:
Byhahn, C; Wilke, HJ; Westphal, K;
Indirizzi:
JW Goethe Univ Hosp Ctr, Dept Anesthesiol Intens Care Med & Pain Control, D-60590 Frankfurt, Germany JW Goethe Univ Hosp Ctr Frankfurt Germany D-60590 590 Frankfurt, Germany
Titolo Testata:
CNS DRUGS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 197 - 215
SICI:
1172-7047(2001)15:3<197:OETVA->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGES; OPERATING-ROOM PERSONNEL; WASTE-GAS EXPOSURE; SPRAGUE-DAWLEY RATS; NITROUS-OXIDE; ANESTHETIC-GASES; ISOFLURANE ANESTHESIA; DROSOPHILA-MELANOGASTER; SEVOFLURANE ANESTHESIA; PEDIATRIC BRONCHOSCOPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Byhahn, C JW Goethe Univ Hosp Ctr, Dept Anesthesiol Intens Care Med & PainControl, Theodor Stern Kai 7, D-60590 Frankfurt, Germany JW Goethe Univ Hosp Ctr Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
C. Byhahn et al., "Occupational exposure to volatile anaesthetics - Epidemiology and approaches to reducing the problem", CNS DRUGS, 15(3), 2001, pp. 197-215

Abstract

Long term occupational exposure to trace concentrations of volatile anaesthetics is thought to have adverse effects on the health of exposed personnel. In contrast with halothane - an agent likely to cause mutagenic effects and proven to be teratogenic - isoflurane and enflurane have not so far been proved to have adverse effects on the health of personnel exposed long term. Data on the newer agents sevoflurane and desflurane are limited. Since possible health hazards from long term exposure to inhalational anaesthetics cannot yet be definitively excluded, many Western countries have established limits for exposure. These usually range from 2 to 10 ppm as a time-weighted average over the time of exposure. A number of investigations have demonstrated that, in operating theatres with modern climate control and waste anaesthetic gas scavenging systems, occupational exposure is unlikely to exceed threshold limits. However, occupational exposure from the use of volatile agents in operating theatres with poor air control - especially during bronchoscopy procedures in paediatric patients - remains a source of concern. This also holds true for both postanaesthesia care units (PACU) and intensive care units (ICU) lacking proper air conditioning and waste gas scavengers. To minimise occupational exposure to volatile anaesthetics, all measures must be taken to provide climate control and properly working scavenging devices, and ensure sufficient personal skill of the anaesthetist, e.g. duringinhalational mask induction. Furthermore, low-flow anaesthesia should be used whenever possible. The sole use of intravenous drugs such as propofol instead of volatile agents, were this possible, would eliminate occupationalexposure, but may result in environmental pollution by toxic metabolites (e.g. phenol).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:08:01