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Titolo:
Neuroprotection for ischaemic stroke - An unattainable goal?
Autore:
Liebeskind, DS; Kasner, SE;
Indirizzi:
Univ Penn, Med Ctr, Comprehens Stroke Ctr, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 troke Ctr, Philadelphia, PA 19104 USA Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
CNS DRUGS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 165 - 174
SICI:
1172-7047(2001)15:3<165:NFIS-A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; RANDOMIZED CONTROLLED TRIAL; FOCAL CEREBRAL-ISCHEMIA; CLINICAL-TRIALS; ANIMAL-MODELS; DOUBLE-BLIND; THERAPY; DRUGS; TOLERABILITY; ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Liebeskind, DS Univ Penn, Med Ctr, Comprehens Stroke Ctr, 3 W Gates Bldg,3400 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3 W Gates Bldg,3400 Spruce St Philadelphia PA USA 19104
Citazione:
D.S. Liebeskind e S.E. Kasner, "Neuroprotection for ischaemic stroke - An unattainable goal?", CNS DRUGS, 15(3), 2001, pp. 165-174

Abstract

Neuroprotective therapies for acute ischaemic stroke have yet to be realised despite the determined efforts of basic science and clinical investigators. Progressive elucidation of the complex pathophysiology involved in the ischaemic cascade has led to the development of numerous candidate interventions. Preliminary efficacy in animal models has repeatedly resulted in frustration after extensive clinical testing. Failure in the translation of results from animal models to humans implicates potential limitations of the current drug development process. Reflection on prior studies suggests possible flaws at several stages. Incorporation of standardised guidelines for preclinical testing of putative neuroprotective therapies and modification of clinical trial design. methodology and reporting may improve chances forsuccess. The future of neuroprotection for stroke remains bright in spite of previous disappointments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:19:00