Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hypothalamic paraventricular nucleus and cardiovascular regulation
Autore:
Badoer, E;
Indirizzi:
RMIT Univ, Dept Med Lab Sci, Melbourne, Vic 3001, Australia RMIT Univ Melbourne Vic Australia 3001 ci, Melbourne, Vic 3001, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 1-2, volume: 28, anno: 2001,
pagine: 95 - 99
SICI:
0305-1870(200101/02)28:1-2<95:HPNACR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; RENAL NERVE ACTIVITY; VOLUME EXPANSION; ELECTRICAL-STIMULATION; PARVOCELLULAR NEURONS; LAMINA TERMINALIS; ANESTHETIZED RATS; CONSCIOUS RATS; SPINAL-CORD; HEMORRHAGE;
Keywords:
brood volume regulation; hypothalamic paraventricular nucleus; intermediolateral cell column; rostral ventrolateral medulla; sympathetic nerve regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Badoer, E RMIT Univ, Dept Med Lab Sci, City Campus,GPO Box 2467V, Melbourne, Vic 3001, Australia RMIT Univ City Campus,GPO Box 2467V Melbourne Vic Australia 3001
Citazione:
E. Badoer, "Hypothalamic paraventricular nucleus and cardiovascular regulation", CLIN EXP PH, 28(1-2), 2001, pp. 95-99

Abstract

1. The hypothalamic paraventricular nucleus (PVN) is an important integrative site within the brain composed of magnocellular and parvocellular neurons. It is known to influence sympathetic nerve activity.2, The parvocellular PVN contains neurons that project to the intermediolateral cell column of the thoraco-lumbar spinal cord (IML). This defines thePVN as an autonomic 'premotor nucleus', one of only five present within the brain.3, Another projection arising from the PVN is a prominent innervation of the presser region of the rostral ventrolateral medulla (RVLM), also a premotor nucleus. The distribution of the PVN neurons projecting to the RVLM is similar to that of the PVN neurons that project to the IML.4. It has been found that up to 30% of spinally projecting neurons in the PVN also send collaterals to the RVLM. Thus, there are neurons in the PVN that can: (i) directly influence sympathetic nerve activity (via PVN-IML connections); (ii) indirectly influence sympathetic nerve activity (via PVN-RVLM connections); and (iii) both directly and indirectly influence sympathetic nerve activity (via neurons with collaterals to the IML and RVLM).5, In the rat, results of studies using the protein Fos to identify activated neurons in the brain suggest that neurons in the PVN with projections to the IML or RVLM mag be activated by decreases in blood volume.6, In conclusion, the PVN can influence sympathetic nerve activity Within the PVN are neurons with anatomical connections that enable them to affect sympathetic nerve activity either directly indirectly or via both mechanisms (via collaterals). Studies that hare examined the role of specific subgroups within the PVN suggest that PVN neurons with connections to the IML or to the RVLM may play a role in the reflex changes in sympathetic nerve activity that are involved in blood volume regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:19:02