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Titolo:
A predicted cortical serotonergic/cholinergic/gabaergic interface as a site of pathology in schizophrenia
Autore:
Dean, B;
Indirizzi:
Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 1-2, volume: 28, anno: 2001,
pagine: 74 - 78
SICI:
0305-1870(200101/02)28:1-2<74:APCSIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOLATERAL PREFRONTAL CORTEX; RECEPTOR MESSENGER-RNAS; CENTRAL-NERVOUS-SYSTEM; RAT CEREBRAL-CORTEX; ACETYLCHOLINE-RELEASE; DOWN-REGULATION; SEROTONIN(2A) RECEPTORS; MUSCARINIC RECEPTORS; FRONTAL-CORTEX; BRAIN;
Keywords:
acetylcholine; frontal cortex; GABA; 5-hydroxytryptamine; post-mortem; schizophrenia; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dean, B Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Locked Bag 11 Parkville Vic Australia 3052
Citazione:
B. Dean, "A predicted cortical serotonergic/cholinergic/gabaergic interface as a site of pathology in schizophrenia", CLIN EXP PH, 28(1-2), 2001, pp. 74-78

Abstract

1. The pathological process that precipitates schizophrenia has yet to be identified. However, many lines of evidence suggest that a change in the functioning of the frontal cortex is an important abnormality that underlies schizophrenia.2. Studies in Brodmann's area 9, obtained post-mortem, have shown changes in 5-hydroxytryptamine 5-HT2A, muscarinic M-1 and GABA(A), receptors in tissue from subjects with schizophrenia,3. Animal studies suggest a site in the cortex where there would be an interaction between serotonergic and cholinergic innervation and that this interaction would involve the 5-HT2A and the M-1 receptor. This site, in turn,would be a potent modulator of GABA activity and, hence, levels of GABA(A)receptors,4. From combining these data, a theoretical site is proposed that, if proven to exist in human cortex, is likely to be central to the pathology of that illness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 04:23:45