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Titolo:
A proposed pathological model in the hippocampus of subjects with schizophrenia
Autore:
Scarr, E; Copolov, DL; Dean, B;
Indirizzi:
Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Rebecca L Cooper ResLabs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 1-2, volume: 28, anno: 2001,
pagine: 70 - 73
SICI:
0305-1870(200101/02)28:1-2<70:APPMIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; RAT FRONTAL-CORTEX; ACETYLCHOLINE-RELEASE; SEROTONIN TRANSPORTER; MODULATION;
Keywords:
acetylcholine; hippocampus; 5-hydroxytryptamine; schizophrenia; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Scarr, E Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Rebecca L Cooper ResLabs, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Locked Bag 11 Parkville Vic Australia 3052
Citazione:
E. Scarr et al., "A proposed pathological model in the hippocampus of subjects with schizophrenia", CLIN EXP PH, 28(1-2), 2001, pp. 70-73

Abstract

1. The hippocampal formation plays an important role in the normal functioning of the brain, being implicated in cognition and sensory gating, both of which are affected in schizophrenia. The hippocampal formation receives information from the association cortices, which is processed by glutamatergic transmission within the hippocampus, Dopamine, noradrenaline, 5-hydroxytryptamine (5-HT), acetylcholine and GABA, all of which have been proposed to play a role in the neurobiology of schizophrenia, can affect this transmission.2. The advent of the 'atypical' antipsychotics, with their broad pharmacological spectra and improved therapeutic outcome, has revitalized research into neurotransmitter dysfunction other than that of dopamine. In particular, there has been interest in the serotonergic and cholinergic systems within the hippocampal formation because these are two of the transmitter systems targeted by clozapine and olanzapine,3. From the study of these systems, using tissue obtained post-mortem fromsubjects with schizophrenia, we propose that there is a hyperserotonergic state in the hippocampal formation of some subjects with schizophrenia caused by a conformational change in the 5-HT transporter, The model we proposeallows us to construct further studies that will test the consequences of such a hyperserotonergic state in the hippocampal formation. This model hasthe potential to open new avenues in schizophrenia research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:29:49