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Titolo:
Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats
Autore:
Mizutani, K; Ikeda, K; Kawai, Y; Yamori, Y;
Indirizzi:
Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept Int Prevent Nutr Med, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Nutr Med, Sakyo Ku, Kyoto 6068501, Japan Sunstar Inc Co, Div Res, Hlth Care R&D Dept, Osaka, Japan Sunstar Inc Co Osaka Japan o, Div Res, Hlth Care R&D Dept, Osaka, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 1-2, volume: 28, anno: 2001,
pagine: 55 - 59
SICI:
0305-1870(200101/02)28:1-2<55:PEOROO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN-PEROXIDE PRODUCTION; DEPENDENT DIABETES-MELLITUS; GLYCATION END-PRODUCTS; SMOOTH-MUSCLE CELLS; DNA-DAMAGE; URINARY 8-HYDROXY-2'-DEOXYGUANOSINE; BIOMECHANICAL PROPERTIES; BIOMARKER EVIDENCE; MAILLARD REACTION; NITRIC-OXIDE;
Keywords:
advanced glycation end-products; oxidative stress; phytoestrogen; resveratrol; stroke-prone spontaneously hypertensive rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mizutani, K Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept IntPrevent Nutr Med, Sakyo Ku, Nihonmatsu Cho, Kyoto 6068501, Japan Kyoto Univ Nihonmatsu Cho Kyoto Japan 6068501 6068501, Japan
Citazione:
K. Mizutani et al., "Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats", CLIN EXP PH, 28(1-2), 2001, pp. 55-59

Abstract

1. In the present study, we examined the effect of resveratrol (3,4',5-trihydroxystilbene), a phytoestrogen found in the skins of most grapes, on oxidative DNA damage in male and female stroke-prone spontaneously hypertensive rats (SHRSP),2. Five-week-old male and female SHRSP were divided into control and resveratrol groups, The resveratrol group was given 1 mg/kg per day, orally, resveratrol by gastric intubation once a day,3. Following an 8 week feeding period, the levels of 8-hydroxydeoxyguanosine (8-OHdG), produced from deoxyguanosine under conditions of oxidative stress, in the urine of male and female resveratrol-treated SHRSP were significantly lower than that in control SHRSP.4. The urine of resveratrol-treated male and female SHRSP had lower levelsof hydroperoxide compared with control SHRSP, but the difference was not significant.5. Treatment with resveratrol resulted in a 25 and 30% reduction in plasmaglycated albumin in male and female SHRSP, respectively, compared with controls.6. Gender differences for SHRSP with regard to 8-OHdG, hydroperoxide and glycated albumin levels mere not confirmed, resveratrol having similar protective effects on male and female SHRSP.7. These results indicate that dietary resveratrol: (i) plays a role in suppressing oxidative DNA damage and glycoxidative stress in vivo; and (ii) has similar protective effects in both male and female SHRSP, suggesting that the direct effects of this phytoestrogen on oxidative stress in vivo are not sexually dimorphic.

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Documento generato il 25/09/20 alle ore 22:50:12