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Titolo:
Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat
Autore:
Watanabe, TK; Okuno, S; Ono, T; Yamasaki, Y; Oga, K; Mizoguchi-Miyakita, A; Miyao, H; Suzuki, M; Momota, H; Goto, Y; Shinomiya, H; Hishigaki, H; Hayashi, I; Asai, T; Wakitani, S; Takagi, T; Nakamura, Y; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710192 7710192, Japan Osaka Minami Natl Hosp, Dept Orthopaed Surg, Osaka, Japan Osaka Minami Natl Hosp Osaka Japan p, Dept Orthopaed Surg, Osaka, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Database, Tokyo, Japan Univ Tokyo Tokyo Japan Human Genome, Lab Genome Database, Tokyo, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan UnivTokyo Tokyo Japan Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 1-2, volume: 28, anno: 2001,
pagine: 28 - 42
SICI:
0305-1870(200101/02)28:1-2<28:SCOTDL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOKUSHIMA-FATTY RAT; QUANTITATIVE TRAIT LOCI; RADIATION HYBRID MAP; GENETIC DISSECTION; SPONTANEOUS NIDDM; GK RAT; MELLITUS; MODEL; HYPERTRIGLYCERIDEMIA; IDENTIFICATION;
Keywords:
congenic; diabetes; Dmo1; dyslipidaemia; genetic analysis; obesity; Otsuka Long Evans Tokushima Fatty rat; quantitative trait locus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, TK Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 Kagasuno, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Tokushima Japan 7710192
Citazione:
T.K. Watanabe et al., "Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat", CLIN EXP PH, 28(1-2), 2001, pp. 28-42

Abstract

1. Whole-genome scans have identified Dmo1 as a major quantitative trait locus for dyslipidaemia and obesity in the Otsuka Long Evans Tokushima Fatty(OLETF) rat.2. We have produced congenic rats for the Dmo1 locus through successive back-cross breeding with diabetic OLFTF rats. Marker-assisted speed congenic protocols were applied to efficiently transfer chromosomal segments from non-diabetic Brown Norway (BN) rats into the OLETF background.3. In the fourth generation of congenic animals, we observed a substantialtherapeutic effect of the Dmo1 locus on lipid metabolism. obesity control and plasma glucose homeostasis,4. We have concluded that Dmo1 primarily affects lipid homeostasis, obesity control and/or glucose homeostasis at fasting and is secondarily involvedin glucose homeostasis after loading.5. The results of the present study show that single-allele correction of a genetic defect of the Dmo1 locus can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes.

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Documento generato il 23/01/20 alle ore 03:45:37