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Titolo:
A comparative study of the ability of ferric nitriloacetate and other ironchelators to assist membrane lipid peroxidation by superoxide radicals
Autore:
Fukuzawa, K; Tokumura, A; Kogure, K; Iemura, M; Gondoh, N; Fujii, M; Ueno, S; Shibata, A;
Indirizzi:
Univ Tokushima, Sch Med Sci, Dept Hlth Chem, Tokushima 7708505, Japan UnivTokushima Tokushima Japan 7708505 th Chem, Tokushima 7708505, Japan Univ Tokushima, Sch Med Sci, Dept Med Technol, Tokushima 7708505, Japan Univ Tokushima Tokushima Japan 7708505 Technol, Tokushima 7708505, Japan Univ Tokushima, Sch Med Sci, Dept Phys Chem, Tokushima 7708505, Japan UnivTokushima Tokushima Japan 7708505 ys Chem, Tokushima 7708505, Japan
Titolo Testata:
CHEMISTRY AND PHYSICS OF LIPIDS
fascicolo: 1, volume: 110, anno: 2001,
pagine: 69 - 84
SICI:
0009-3084(200103)110:1<69:ACSOTA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRON(III) COMPLEXES; HYDROGEN-PEROXIDE; OXIDATIVE DAMAGE; TISSUE-DAMAGE; METAL-IONS; NITRILOTRIACETATE; INDUCTION; MECHANISMS; CANCER; MODEL;
Keywords:
lipid peroxidation; superoxide; iron; nitrilotriacetate; xanthine oxidase; carcinogenesis; liposomes; membrane charge; free radical; chelate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Fukuzawa, K Univ Tokushima, Sch Med Sci, Dept Hlth Chem, 1-78 Shomachi, Tokushima 7708505, Japan Univ Tokushima 1-78 Shomachi Tokushima Japan 7708505 5, Japan
Citazione:
K. Fukuzawa et al., "A comparative study of the ability of ferric nitriloacetate and other ironchelators to assist membrane lipid peroxidation by superoxide radicals", CHEM PHYS L, 110(1), 2001, pp. 69-84

Abstract

This study examined some of the variables determining the efficiency of lipid peroxidation in egg yolk phosphatidylcholine liposomes and in microsomes exposed to enzymatically-generated superoxide radicals. The initiation ofperoxidation required the presence of preformed lipid peroxides and a chelated metal catalyst. Comparison of the relative effectiveness of four iron chelating agents showed that the chelate must bind to the membrane by coulombic attraction between the charged membrane and a chelate carrying an opposite net charge. Of the chelates tested, only the carcinogenic ferric nitriloacetate (Fe3+-NTA) was an effective catalyst of oxidation of all membranes, whether carrying a net charge, or not. We postulate that the unique catalytic capacity of the ferric nitriloacetate (Fe3+-NTA) can be explained by its existence in two forms at neutral pH, each binding to oppositely charged membranes and initiating their peroxidation. This gives the complex the unique ability to bind to any membrane, which may be a factor in its carcinogenicity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:45:10