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Titolo:
A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A
Autore:
Stander, MA; Steyn, PS; van der Westhuizen, FH; Payne, BE;
Indirizzi:
Univ Stellenbosch, Dept Chem, ZA-7602 Stellenbosch, South Africa Univ Stellenbosch Stellenbosch South Africa ZA-7602 nbosch, South Africa Potchefstroom Univ Christian Higher Educ, ZA-2520 Potchefstroom, South Africa Potchefstroom Univ Christian Higher Educ Potchefstroom South Africa ZA-2520
Titolo Testata:
CHEMICAL RESEARCH IN TOXICOLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 302 - 304
SICI:
0893-228X(200103)14:3<302:AKSITH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYLALANINE; INHIBITION; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Steyn, PS Univ Stellenbosch, Dept Chem, Private Bag X1, ZA-7602 Stellenbosch, South Africa Univ Stellenbosch Private Bag X1 Stellenbosch South Africa ZA-7602
Citazione:
M.A. Stander et al., "A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A", CHEM RES T, 14(3), 2001, pp. 302-304

Abstract

The hydrolyses of the ochratoxins and analogues by carboxypeptidase A wereassessed. This was done by measuring the amount of phenylalanine formed with liquid chromatography coupled to tandem electrospray mass spectrometry. The kinetic data of ochratoxin A, ochratoxin B, and the synthetic bromo-ochratoxin B were compared to the values of a number of synthesized structure analogues, namely, ochratoxin A methyl ester, ochratoxin B methyl ester, N-(2-hydroxybenzoyl)phenylalanine, N-(5-chloro-2-hydroxybenzoyl)phenylalanine, N-(5-bromo-2-hydroxybenzoyl)phenylalanine, and N-(5-fluoro-2-hydroxybenzoyl)phenylalanine, and N-(5-fluoro-2-hydroxybenzoyl)phenylalanine, The halogen-containing analogues had lower turnovers than their des-halo analogues. There are no substantial differences in the kinetic data between the different halogen-containing analogues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 21:05:53