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Titolo:
EFFECT OF ANTI-APOPTOTIC GENES AND PEPTIDE INHIBITORS ON CYTOPLASMIC ACIDIFICATION DURING APOPTOSIS
Autore:
PARDHASARADHI BVV; KHAR A; SRINIVAS UK;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 411, anno: 1997,
pagine: 67 - 70
SICI:
0014-5793(1997)411:1<67:EOAGAP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; RAT HISTIOCYTOMA; AK-5; IDENTIFICATION; REGRESSION; MECHANISM; PROTEASE;
Keywords:
TUMOR CELL APOPTOSIS; PH REDUCTION; ANTIAPOPTOTIC GENE; PEPTIDE INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
B.V.V. Pardhasaradhi et al., "EFFECT OF ANTI-APOPTOTIC GENES AND PEPTIDE INHIBITORS ON CYTOPLASMIC ACIDIFICATION DURING APOPTOSIS", FEBS letters, 411(1), 1997, pp. 67-70

Abstract

Cytoplasmic acidification has been shown to occur during the apoptotic process of cell death although its relation with other events in theprocess are not yet clear. AK-5 tumor cells have been shown to undergo apoptosis upon treatment with stimuli like dexamethasone (1 mu M) orwith serum from animals that reject AK-5 tumor. The current study wasdesigned to measure the extent of cytoplasmic acidification during apoptosis in AK-5 cells and to study the effect of antiapopoptic genes and peptide inhibitors on cytoplasmic acidification, Our results show that AK-5 cells when triggered into apoptosis show intracellular acidification by about 0.2 pH units and this is prevented when cells are treated with peptide inhibitors, In addition cytoplasmic acidification does not occur when AK-5 cells are transfected with anti-apoptotic genesNedd-2 A.S, Crm A or bcl-2 which inhibit apoptosis. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:29:34