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Titolo:
beta-adrenoceptor blockade alters thymocyte differentiation in aged mice
Autore:
Madden, KS; Felten, DL;
Indirizzi:
Univ Rochester, Sch Med & Dent, Ctr Psychoneuroimmunol Res, Rochester, NY USA Univ Rochester Rochester NY USA sychoneuroimmunol Res, Rochester, NY USA Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642USA Univ Rochester Rochester NY USA 14642 biol & Anat, Rochester, NY 14642USA
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 189 - 196
SICI:
0145-5680(200102)47:1<189:BBATDI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT THYMUS; LYMPHOCYTES; INNERVATION; CELLS; SYMPATHECTOMY; ACQUISITION; EXPRESSION; IMMATURE;
Keywords:
thymus development; aging; sympathetic nervous system; neural-immune interactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Felten, DL Loma Linda Univ, Dept Pathol & Human Anat, Ctr Neuroimmunol, 11021 Campus St, Loma Linda, CA 92350 USA Loma Linda Univ 11021 Campus St Loma Linda CA USA 92350 350 USA
Citazione:
K.S. Madden e D.L. Felten, "beta-adrenoceptor blockade alters thymocyte differentiation in aged mice", CELL MOL B, 47(1), 2001, pp. 189-196

Abstract

The thymus is the primary site for generation of naive T-lymphocytes in the young animal. With age, the thymus progressively involutes and fewer mature T-cells are produced and migrate to the periphery. With thymic involution, increased density of sympathetic noradrenergic (NA) innervation and concentration of norepinephrine (NE) have been observed. To determine if the age-related changes in thymocyte differentiation are modified by NE signalingthrough beta -adrenergic receptors, 2-month (mo) and 18-mo old BALB/c micewere implanted subcutaneously with pellets containing the non-selective beta -adrenoceptor antagonist nadolol. Four and one-half weeks later, thymus and peripheral blood were collected to assess changes in thymocyte differentiation and naive T-cell output by flow cytometric analysis of T-cell subpopulations. In old mice, but not in young mice, thymocyte CD4/CD8 co-expression was altered by beta -adrenoceptor blockade. In nadolol-treated old mice, the frequency of the immature CD4(-)8(-) population was increased, and the intermediate CD4(+)8(+) population was reduced. A corresponding increase in the frequency of mature CD4(-)8(+), but not CD4(+)8(-) cells was observed. The increase in CD4-8+ cells is most likely not mediated by more CD4(+)8(+) cells undergoing positive selection, because CD3(hi) expression in the CD4(+)8(+) population was not altered by nadolol. The percentage of CD8(+)44(low) naive cells in peripheral blood increased in nadolol-treated mice, suggesting that more CD4(-)8(+) cells were exported from the thymus to the periphery. These results indicate that the age-associated increase in sympathetic NA innervation of the thymus modulates thymocyte maturation. Pharmacological manipulation of NA innervation may provide a novel means of increasing naive T-cell output and improving T-cell reactivity to novel antigens with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:24:35