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Titolo:
Development-related expression of AKAP79 in the striatal compartments of the human brain
Autore:
Ulfig, N; Neudorfer, F; Bohl, J;
Indirizzi:
Univ Rostock, Dept Anat, Neuroembryon Res Lab, D-18055 Rostock, Germany Univ Rostock Rostock Germany D-18055 n Res Lab, D-18055 Rostock, Germany Univ Mainz, Dept Neuropathol, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Dept Neuropathol, D-6500 Mainz, Germany
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 4, volume: 168, anno: 2001,
pagine: 319 - 329
SICI:
1422-6405(2001)168:4<319:DEOAIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; TYROSINE-HYDROXYLASE; ANCHORING PROTEINS; BASAL GANGLIA; PHOSPHORYLATION; PATTERNS; NEURONS; FETAL; LOCALIZATION; NEOSTRIATUM;
Keywords:
striosomes; patches; matrix; kinase anchoring protein; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ulfig, N Univ Rostock, Dept Anat, Neuroembryon Res Lab, Gertrudenstr 9, D-18055 Rostock, Germany Univ Rostock Gertrudenstr 9 Rostock Germany D-18055ock, Germany
Citazione:
N. Ulfig et al., "Development-related expression of AKAP79 in the striatal compartments of the human brain", CELLS T ORG, 168(4), 2001, pp. 319-329

Abstract

The expression of AKAP79 which tethers regulatory proteins within postsynaptic densities has been studied in the two striatal compartments, i.e. patches and matrix, at different stages of the developing human brain by means of immunohistochemistry. The two striatal compartments exhibit various intensities of diffuse immunolabelling and a different number of immunoreactivenerve cells. From the 14th to 20th gestational week a nearly homogeneous distribution of immunoreactive structures in the two compartments of the striatum is seen. Thereafter, a decrease in immunoreactive structures within the matrix is observed (22nd-25th week, intermediate stage). From the 27th week onwards the patch compartment contains distinctly more immunoreactive puncta and nerve cells. Thus, the patches stand out clearly in the immunopreparations. This distribution pattern does not change during proceeding development. AKAP79-immunoreactive nerve cells closely resemble those constituting the class of medium-sized inhibitory projection neurons that receive the dopaminergic input of the striatum. Literature data suggest that AKAP79 may be functionally attributed to dopaminergic inputs. Accordingly, the patterns of AKAP79 expression can at least in part be correlated with the sequential occurrence of dopaminergic innervation. The mature matrix containing a dopaminergic innervation being as dense as in the patches displays distinctly less AKAP79-immunoreactive neurons and puncta than the patches. This discrepancy might indicate that a subpopulation of matrix neurons may, despite dopaminergic input, not express AKAP79. Copyright (C) 2001 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:39:45