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Titolo:
Delta opioid peptide augments functional effects and intrastriatal graft survival of rat fetal ventral mesencephalic cells
Autore:
Borlongan, CV; Su, TP; Wang, Y;
Indirizzi:
NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA NIDA BaltimoreMD USA 21224 ral Res Program, NIH, Baltimore, MD 21224 USA
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 1, volume: 10, anno: 2001,
pagine: 53 - 58
SICI:
0963-6897(200101/02)10:1<53:DOPAFE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROTROPHIC FACTOR; DOPAMINERGIC-NEURONS; FIBER OUTGROWTH; BEHAVIORAL RECOVERY; PARKINSONS-DISEASE; NIGRAL GRAFTS; LINE; TRANSPLANTATION; TISSUE; STRIATUM;
Keywords:
Parkinson's disease; neural transplantation; fetal mesencephalic cells; substantia nigra; striatum; 6-hydroxydopamine; tyrosine hydroxylase; locomotor behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Borlongan, CV NIDA, Intramural Res Program, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 D 21224 USA
Citazione:
C.V. Borlongan et al., "Delta opioid peptide augments functional effects and intrastriatal graft survival of rat fetal ventral mesencephalic cells", CELL TRANSP, 10(1), 2001, pp. 53-58

Abstract

Delta enkephalin analogue [D-Ala(2),D-Leu(5)]enkephalin (DADLE) has been shown to protect dopamine transporters from methamphetamine-induced neurotoxicity. In the present study, we demonstrate that exposure of embryonic ventral mesencephalic cells to DADLE (0.01 g/ml). prior to intrastriatal transplantation. enhanced functional recovery and graft survival in 6-hydroxydopamine-induced hemiparkinsonian rats. At 6 and 8 weeks posttransplantation, animals that received DADLE-treated cell grafts exhibited significantly higher (near normal) spontaneous locomotor behaviors, as well as trends of greater reversal of motor asymmetrical behaviors compared with animals that received nontreated cell grafts. Histological examination revealed that animals transplanted with DADLE-treated cell grafts exhibited about twice the number of surviving tyrosine hydroxylase-immunoreactive grafted neurons compared with those animals that received nontreated cell grafts. These results suggest that DADLE should be considered as an adjunctive agent for neural transplantation therapy in Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:08:59