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Titolo:
Adult bone marrow transplantation after stroke in adult rats
Autore:
Li, Y; Chen, JL; Chopp, M;
Indirizzi:
Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hlth Sci Ctr Detroit MI USA 48202 eurol, Detroit, MI 48202 USA Oakland Univ, Dept Phys, Rochester, MI 48309 USA Oakland Univ Rochester MI USA 48309 v, Dept Phys, Rochester, MI 48309 USA
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 1, volume: 10, anno: 2001,
pagine: 31 - 40
SICI:
0963-6897(200101/02)10:1<31:ABMTAS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; STROMAL CELLS; HEMATOPOIETIC-CELLS; HUNTINGTONS-DISEASE; PROGENITOR CELLS; STEM-CELLS; CYCLIN D1; EXPRESSION; SURVIVAL;
Keywords:
bone marrow; transplantation; stroke; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Chopp, M Henry Ford Hosp, Dept Neurol, 2799 W Grand Blvd, Detroit, MI 48202 USA Henry Ford Hosp 2799 W Grand Blvd Detroit MI USA 48202 48202 USA
Citazione:
Y. Li et al., "Adult bone marrow transplantation after stroke in adult rats", CELL TRANSP, 10(1), 2001, pp. 31-40

Abstract

We transplanted adult whole bone marrow prelabeled with bromodeoxyuridine (BrdU) into the ischemic boundary zone of the adult rat brain at 1 day after 2 h of middle cerebral artery occlusion (MCAo). Approximately 3.3% of 10(6) transplanted bone marrow cells were BrdU reactive at 14 days after MCAo. BrdU reactive cells expressed neuronal and astrocytic proteins. neuronal nuclei protein (NeuN, 1%), and glial fibrillary acidic protein (GFAP, 5%) immunoreactivities. respectively. In addition, bone marrow transplantation promoted proliferation of ependymal and subependymal cells, identified by nestin (a neuroepithelial stem cell marker), within the ventricular zone and subventricular zone (VZ/SVZ). These data suggest that intracerebral transplantation of bone marrow could potentially be used to induce plasticity in ischemic brain.

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Documento generato il 25/11/20 alle ore 00:59:14