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Titolo:
BIOLOGY AND ADOPTIVE CELL THERAPY OF EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS IN RECIPIENTS OF MARROW ALLOGRAFTS
Autore:
OREILLY RJ; SMALL TN; PAPADOPOULOS E; LUCAS K; LACERDA J; KOULOVA L;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT PEDIAT,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,MARROW TRANSPLANTAT SERV NEW YORK NY 10021
Titolo Testata:
Immunological reviews
, volume: 157, anno: 1997,
pagine: 195 - 216
SICI:
0105-2896(1997)157:<195:BAACTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NON-HODGKINS-LYMPHOMA; VERSUS-HOST DISEASE; INDUCED INFECTIOUS-MONONUCLEOSIS; HLA CLASS-I; HEALTHY SEROPOSITIVE INDIVIDUALS; LATENT MEMBRANE PROTEIN-1; CYTOTOXIC LYMPHOCYTES-T; NUCLEAR ANTIGEN EBNA-1; TUMOR-NECROSIS-FACTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
182
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Oreilly et al., "BIOLOGY AND ADOPTIVE CELL THERAPY OF EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS IN RECIPIENTS OF MARROW ALLOGRAFTS", Immunological reviews, 157, 1997, pp. 195-216

Abstract

Epstein-Barr virus (EBV) is an ubiquitous herpesvirus which is carried as a latent infection of B lymphocytes and salivary gland epithelialcells in over 90% of normal adults. Latently infected EBV-transformedB cells circulate at low frequency in the blood for the life of the host. These transformed B cells stimulate a heterogeneous and complex host cell response, ultimately leading to the development and maintenance of high frequencies of HLA-restricted T cells specific for the EBV-encoded nuclear antigens EBNA2-EBNA6 and the latency membrane proteinsLMP-1 and LMP-2. Responses to latent EBV-encoded proteins are hierarchical with responses to certain epitopes predominating, dependent uponthe HLA genotype of the host. Profound suppression of T-cell immunitymay permit the emergence of polyclonal, oligoclonal or monoclonal EBVantigen-expressing lymphoproliferative disorders or malignant B-cell lymphomas expressing these latent EBV antigens. Adoptive transfer of small numbers of peripheral blood mononuclear cells or HLA-partially matched T cells from in vitro expanded EBV-specific T-cell lines derivedfrom a seropositive marrow donor has induced durable regressions of bulky, widely metastatic monoclonal EBV lymphomas in a high proportion of cases. This review describes the current state of knowledge and hypothesis regarding the biology and immunology of EBV infection in the normal host, the features of donor, host and virus which contribute to the development of EBV-associated lymphoproliferative diseases and themechanisms whereby they are controlled by adoptive transfer of immuneT cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:00:13