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Titolo:
Myxoid leiomyosarcoma of the left atrium: A rare malignancy of the heart and its comparison with atrial myxoma
Autore:
Morin, JE; Rahal, DP; Huttner, I;
Indirizzi:
McGill Univ, Ctr Hlth, Dept Cardiovasc Surg, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Surg, Montreal, PQ H3A 1A1, Canada McGill Univ, Ctr Hlth, Dept Cardiol, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 diol, Montreal, PQ H3A 1A1, Canada McGill Univ, Ctr Hlth, Dept Pathol, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 thol, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
CANADIAN JOURNAL OF CARDIOLOGY
fascicolo: 3, volume: 17, anno: 2001,
pagine: 331 - 336
SICI:
0828-282X(200103)17:3<331:MLOTLA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC MYXOMAS; THERAPY;
Keywords:
atria; pathology; surgery; tumour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Morin, JE McGill Univ, Ctr Hlth, Dept Cardiovasc Surg, 687 Pine Ave W,RoomS-830, Montreal, PQ H3A 1A1, Canada McGill Univ 687 Pine Ave W,Room S-830 Montreal PQ Canada H3A 1A1
Citazione:
J.E. Morin et al., "Myxoid leiomyosarcoma of the left atrium: A rare malignancy of the heart and its comparison with atrial myxoma", CAN J CARD, 17(3), 2001, pp. 331-336

Abstract

Primary rumours of the heart are rare. The majority of these tumours are benign, with myxomas located in the left atrium being the most common form. Almost all malignant rumours are sarcomas and occur preferentially in the right side of the heart. An exception to this rule is leiomyosarcoma, a rareform of primary cardiac sarcoma that occurs predominantly in the left atrium, as does cardiac myxoma. The case of a 53-year-old woman who presented with symptoms of mitral valve stenosis and pulmonary hypertension is reported. Cardiac catheterization, angiography and echocardiography revealed a left atrial mass that was interpreted as atrial myxoma. At the time of operation, the myxoid appearance of the tumour mass further supported this assumption. The tumour, including a wide rim of atrial septum, was removed with cautery. Histopathological examination unexpectedly showed that the tumour was not an atrial myxoma but rather a myxoid variant of a primary leiomyosarcoma. Immunohistochemistry and electron microscopy confirmed the diagnosis. Local radiotherapy was considered but deemed con traindicated in View of the longstanding pulmonary hypertension. Two months after excision, a repeatechocardiogram indicated recurrence of tumour in the left atrium, and the patient died a few days later. The preferential left atrial location and the frequently myxoid appearance of primary leiomyosarcomas of the heart makeit particularly difficult to differentiate them preoperatively from atrialmyxomas. The authors recommend resection of ail atrial myxoid rumours witha wide (at least 1 cm) margin, combined with intraoperative frozen sectiondiagnosis, because complete surgical resection appears to correlate with prolonged survival in the few reported cases of atrial leiomyosarcomas. In cases of incomplete initial resection or local recurrence in the absence of metastatic disease, heart transplantation may be a valid option in appropriately selected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:06:47