Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab
Autore:
Willenbacher, W; Basara, N; Blau, IW; Fauser, AA; Kiehl, MG;
Indirizzi:
BMT Programme, Clin Haematol Oncol, D-55743 Idaroberstein, Germany BMT Programme Idaroberstein Germany D-55743 55743 Idaroberstein, Germany
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 112, anno: 2001,
pagine: 820 - 823
SICI:
0007-1048(200103)112:3<820:TOSRAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; RECEPTOR ANTIBODY; RANDOMIZED TRIAL; CYCLOSPORINE; METHOTREXATE; PROPHYLAXIS; PREVENTION; PREDNISONE; REJECTION; ATG;
Keywords:
graft-versus-host disease; BMT; daclizumab; interleukin 2 receptor antibody; GVHD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kiehl, MG BMT Programme, Clin Haematol Oncol, Dr Ottmar Kohler Str 2, D-55743 Idaroberstein, Germany BMT Programme Dr Ottmar Kohler Str 2 Idaroberstein Germany D-55743
Citazione:
W. Willenbacher et al., "Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab", BR J HAEM, 112(3), 2001, pp. 820-823

Abstract

Competitive inhibition of interleukin 2-dependent lymphocytes by daclizumab demonstrates some beneficial effects in the treatment of graft-versus-host disease (GVHD), Sixteen patients with steroid refractory GVHD received daclizumab (1 mg/kg BW) on d 1, 2 (-5), 7, 14 and 21. Twelve patients suffered from grade LU-nr acute GVHD and four patients from extensive chronic GVHD. Responses were observed in nine patients (six acute, three chronic GVHD). Fourteen out of 16 patients acquired infections during daclizumab treatment and three deaths were infection related. Daclizumab demonstrates limited activity and is associated with an increased incidence of infectious complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:12:03