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Titolo:
Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women
Autore:
Reiner, AP; Schwartz, SM; Kumar, PN; Rosendaal, FR; Pearce, RM; Aramaki, KM; Psaty, BM; Siscovick, DS;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA USA Univ Washington Seattle WA USA shington, Dept Epidemiol, Seattle, WA USA Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA Univ Washington Seattle WA USA Cardiovasc Hlth Res Unit, Seattle, WA USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA PSG Inst Med Sci & Res, Dept Pathol, Coimbatore, Tamil Nadu, India PSG Inst Med Sci & Res Coimbatore Tamil Nadu India re, Tamil Nadu, India Univ Leiden Hosp, Dept Clin Epidemiol, Leiden, Netherlands Univ Leiden Hosp Leiden Netherlands Clin Epidemiol, Leiden, Netherlands Univ Leiden Hosp, Haemostasis & Thrombosis Res Ctr, Leiden, Netherlands Univ Leiden Hosp Leiden Netherlands mbosis Res Ctr, Leiden, Netherlands
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 112, anno: 2001,
pagine: 632 - 636
SICI:
0007-1048(200103)112:3<632:PGIPTR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; RECEPTORS; DISEASE; STROKE; HPA-1;
Keywords:
myocardial infarction; glycoprotein IIb; platelet; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, AP Harborview Med Ctr, 325 9th Ave,Box 359756, Seattle, WA 98104 USA Harborview Med Ctr 325 9th Ave,Box 359756 Seattle WA USA 98104
Citazione:
A.P. Reiner et al., "Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women", BR J HAEM, 112(3), 2001, pp. 632-636

Abstract

Several platelet glycoprotein polymorphisms have been associated with an increased risk of myocardial infarction (MI) in studies that included predominantly men. In a population-based sample of 68 Caucasian women <45 years old with non-fatal MI and 346 demographically similar control subjects, we found an increased risk of MI among women who possessed at Least one copy ofthe glycoprotein IIb Ser(843) allele compared with those lacking the Ser(843) allele (odds ratio 1.85: 95% confidence interval = 1.03-3.33). The increased risk was present only in subgroups of women who smoked cigarettes, had hypercholesterolaemia or who had a family history of early onset MI. The Ser(843) variant of glycoprotein IIb may be associated with an increased risk of MI in young women with other cardiovascular risk factors. Additional studies involving larger numbers of subjects are needed to confirm this preliminary finding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:33:55