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Titolo:
Long-term outcome of individualized prophylactic treatment of children with severe haemophilia
Autore:
van den Berg, HM; Fischer, K; Mauser-Bunschoten, EP; Beek, FJA; Roosendaal, G; van der Bom, JG;
Indirizzi:
Univ Utrecht, Med Ctr, Van Creveld Clin, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Paediat, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Radiol, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Julius Ctr Patient Oriented Res, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Haematol, NL-3584 CX Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 112, anno: 2001,
pagine: 561 - 565
SICI:
0007-1048(200103)112:3<561:LOOIPT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEMOPHILIA-A; COST-EFFECTIVENESS; FACTOR-VIII; EXPERIENCE; ARTHROPATHY;
Keywords:
prophylaxis; severe haemophilia; arthropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: van den Berg, HM Univ Utrecht, Med Ctr, Van Creveld Clin, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands Univ Utrecht Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
H.M. van den Berg et al., "Long-term outcome of individualized prophylactic treatment of children with severe haemophilia", BR J HAEM, 112(3), 2001, pp. 561-565

Abstract

The development of arthropathy is a serious complication of severe haemophilia. With the use of prophylaxis, bleeds can be prevented and arthropathy delayed. We investigated whether an individually tailored prophylactic regimen can prevent arthropathy and whether it had a similar effect on orthopaedic outcome compared with that of a high-dose regimen, Efficacy was determined clinically and by radiographs of six major joints. Prophylaxis was started in 70 patients at a mean age of 4.1 years. Mean follow-up was 15.6 years (range 8-24.5 years). The mean factor VIII consumption was 2319 IU/kg/year. The mean number of joint bleeds was 3.5/year and the mean clinical score(maximum score 90) was 1.0, with a mean Pettersson joint score (maximum score 78) of 3.0 at a mean age of 13.5 years. In conclusion, long-term, early-onset, individualized prophylaxis in haemophilia is feasible and prevents arthropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:35:04