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Titolo:
Frequency of cytochrome P4502C9 mutant alleles in a Korean population
Autore:
Yoon, YR; Shon, JH; Kim, MK; Lim, YC; Lee, HR; Park, JY; Cha, IJ; Shin, JG;
Indirizzi:
Inje Univ, Coll Med, Clin Pharmacol Ctr, Dept Pharmacol, Pusan 614735, South Korea Inje Univ Pusan South Korea 614735 Pharmacol, Pusan 614735, South Korea Pusan Paik Hosp, Clin Pharmacol Ctr, Pusan, South Korea Pusan Paik Hosp Pusan South Korea lin Pharmacol Ctr, Pusan, South Korea Chonnam Natl Univ, Coll Med, Dept Pharmacol, Pusan, South Korea Chonnam Natl Univ Pusan South Korea Dept Pharmacol, Pusan, South Korea
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 51, anno: 2001,
pagine: 277 - 280
SICI:
0306-5251(200103)51:3<277:FOCPMA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM; JAPANESE POPULATION; CYP2C9; METABOLISM; VARIANT; (S)-WARFARIN;
Keywords:
CYP2C9; genotype; Korean;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, JG Inje Univ, Coll Med, Clin Pharmacol Ctr, Dept Pharmacol, 633-165,Kaekum Dong, Pusan 614735, South Korea Inje Univ 633-165,Kaekum Dong PusanSouth Korea 614735 uth Korea
Citazione:
Y.R. Yoon et al., "Frequency of cytochrome P4502C9 mutant alleles in a Korean population", BR J CL PH, 51(3), 2001, pp. 277-280

Abstract

Aims To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations. Methods Genotyping of CYP2C9(star)2 and CYPC9 star3 allelic variants was carried out in 574 Korean subjects by PCR and restriction fragment length pattern analysis. Results Thirteen of 574 subjects (2.3%) were heterozygous for CYP2C9 star3(Ile(359)Leu), but no subjects with a CYP2C9 star2 allele or homozygous for CYP2C9 star3 were identified. The allele frequency of CYP2C9 star3 in Korean subjects (0.0113, 95% CI 0.0066-0.0193) was similar to that of-other East Asian populations, but was considerably lower than that of Caucasian populations. Conclusions CYP2C9 star3 seems to be an allelic variant related to the functional polymorphism of CYP2C9. but this variant is rarely seen among Koreans compared with Caucasians. Routine genotyping of the CYP2C9C star2 alleleis considered to be unnecessary in Korean and East Asians, because this allele appears to be extremely rare or absent in these populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:30:01