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Titolo:
Angiogenesis and blood vessel invasion as prognostic indicators for node-negative breast cancer
Autore:
Kato, T; Kameoka, S; Kimura, T; Nishikawa, T; Kasajima, T;
Indirizzi:
Tokyo Womens Med Univ, Sch Med, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ, Sch Med, Dept Surg Pathol, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ, Sch Med, Dept Pathol, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan
Titolo Testata:
BREAST CANCER RESEARCH AND TREATMENT
fascicolo: 3, volume: 65, anno: 2001,
pagine: 203 - 215
SICI:
0167-6806(200102)65:3<203:AABVIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; JAPANESE PATIENTS; HIGH-RISK; MICROVESSEL DENSITY; P53 EXPRESSION; CATHEPSIN-D; FOLLOW-UP; CARCINOMA;
Keywords:
angiogenesis; blood vessel invasion; microvessel density; node-negative breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, T Tokyo Womens Med Univ, Sch Med, Dept Surg 2, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 1628666 6, Japan
Citazione:
T. Kato et al., "Angiogenesis and blood vessel invasion as prognostic indicators for node-negative breast cancer", BREAST CANC, 65(3), 2001, pp. 203-215

Abstract

This study was undertaken to determine the value of angiogenesis and bloodvessel invasion (BVI) using both Factor VIII-related antigen and elastica van Gieson staining in predicting 20-year relapse-free survival (RFS) and 20-year overall survival (OS) rates in Japanese patients with node-negative breast cancer. Two hundred and sixty patients were studied. We investigatednine factors, including angiogenesis (average microvessel count (AMC)), BVI, proliferating cell nuclear antigen (PCNA), p53, c-erbB-2, clinical tumorsize (T), histological grade, tumor necrosis, and lymphatic vessel invasion (LVI). Twenty-five patients (9.6%) had recurrence and 17 patients (6.5%) died of breast cancer. Univariate analysis showed that BVI, AMC, T, histological grade, PCNA, p53, and tumor necrosis were significantly predictive ofRFS or OS. Multivariate analysis showed that AMC, BVI, and T were significant independent factors for RFS or OS. Moreover, the combination of AMC/BVIwas an especially significant factor for RFS or OS (P < 0.0001, P = 0.0003, respectively). When stratified by T, a significant impact of AMC or BVI on RFS was seen in patients with T1, T2, and T3 carcinomas. Multivariate analysis in patients with T2 carcinoma showed that both AMC and BVI were significant independent factors for RFS (P = 0.0231, P = 0.0388, respectively) and OS (P = 0.0331 and P = 0.0479, respectively). AMC, BVI, and T were independent prognostic indicators. As the combined impact of AMC/BVI is especially strong, AMC/BVI is useful in selecting high-risk node-negative breast cancer patients who may be eligible to receive aggressive adjuvant chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:49:23