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Titolo:
A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide
Autore:
Jevtovic-Todorovic, V; Wozniak, DF; Benshoff, ND; Olney, JW;
Indirizzi:
Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Anesthesiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 895, anno: 2001,
pagine: 264 - 267
SICI:
0006-8993(20010323)895:1-2<264:ACEOTN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA ANTAGONIST; RATS; PHARMACOKINETICS; AGE; SEX;
Keywords:
NMDA antagonist; rat cortex; hyperbaric chamber; sex; age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Jevtovic-Todorovic, V Washington Univ, Sch Med, Dept Anesthesiol, 660 S Euclid Ave,POB 8054, St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave,POB 8054 St Louis MO USA 63110
Citazione:
V. Jevtovic-Todorovic et al., "A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide", BRAIN RES, 895(1-2), 2001, pp. 264-267

Abstract

The general anesthetics, nitrous oxide (N2O) and keramine, are NMDA antagonists which, like other NMDA antagonists such as MK801, induce a neurotoxicreaction in the rat brain. For MK801 neurotoxicity, both age and sex are important variables (adult rats are more sensitive than immature rats and females are more sensitive than males). In this study we found that ketamine has this same age and sex dependency profile, and N2O has the same age but not sex dependency. Male and female rats are equally sensitive to N2O neurotoxicity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:28:13