Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Unlike 2-deoxy-D-glucose, 3-O-methyl-D-glucose does not induce long-term potentiation in rat hippocampal slices
Autore:
Xu, YZ; Krnjevic, K;
Indirizzi:
McGill Univ, Anaesthesia Res Dept, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 Dept, Montreal, PQ H3G 1Y6, Canada Univ Sci & Technol, Dept Biol, Hefei 23002, Anhui, Peoples R China Univ Sci & Technol Hefei Anhui Peoples R China 23002 hui, Peoples R China
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 895, anno: 2001,
pagine: 250 - 252
SICI:
0006-8993(20010323)895:1-2<250:U23DNI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL GLUCOSE-UTILIZATION; CA1; 2-DEOXYGLUCOSE; SENSITIVITY; NEURONS; BRAIN; LTP;
Keywords:
CA1 synaptic transmission; EPSP depression; glycolysis; phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Krnjevic, K McGill Univ, Anaesthesia Res Dept, Room 1207,McIntyre Bldg,3655 Drummond St, Montreal, PQ H3G 1Y6, Canada McGill Univ Room 1207,McIntyre Bldg,3655 Drummond St Montreal PQ Canada H3G 1Y6
Citazione:
Y.Z. Xu e K. Krnjevic, "Unlike 2-deoxy-D-glucose, 3-O-methyl-D-glucose does not induce long-term potentiation in rat hippocampal slices", BRAIN RES, 895(1-2), 2001, pp. 250-252

Abstract

Equimolar replacement of 10 mM glucose by 2-deoxy-D-glucose (2-DG) causes substantial depression followed by a sharp and sustained potentiation of CAI field EPSPs. In the present experiments, similar applications of 3-O-methyl-D-glucose, which is also taken up by cells but is not phosphorylated, had only a weak blocking action and elicited no potentiation. Possible explanations for the marked effects of 2-DG include a more rapid block of glycolysis and the production of phosphorylated derivatives of 2-DG. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:19:49