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Titolo:
Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats
Autore:
Kourrich, S; Mourre, C; Soumireu-Mourat, B;
Indirizzi:
Univ Aix Marseille 1, Lab Neurobiol Comportements, CNRS, UMR 6562,IBHOP, F-13388 Marseille 13, France Univ Aix Marseille 1 Marseille France 13 P, F-13388 Marseille 13, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 120, anno: 2001,
pagine: 35 - 46
SICI:
0166-4328(20010408)120:1<35:KAKAKC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ODOR-REWARD ASSOCIATION; LONG-TERM POTENTIATION; POTASSIUM CHANNEL; K+ CHANNELS; ACETYLCHOLINE-RELEASE; SYNAPTIC TRANSMISSION; ALZHEIMERS-DISEASE; MEMBRANE CURRENTS; SPATIAL MEMORY; VOLTAGE-CLAMP;
Keywords:
potassium channel; toxin; hippocampus; memory; olfactory associative task; voltage-dependent K channel; scorpion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Mourre, C Univ Aix Marseille 1, Lab Neurobiol Comportements, CNRS, UMR 6562,IBHOP, Traverse Susini, F-13388 Marseille 13, France Univ Aix Marseille 1Traverse Susini Marseille France 13 France
Citazione:
S. Kourrich et al., "Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats", BEH BRA RES, 120(1), 2001, pp. 35-46

Abstract

Olfactory associative learning was used to investigate the involvement of Ky channels containing Kv1.1 and Kv1.3 alpha -subunits in learning and memory. Kaliotoxin (KTX), a specific inhibitor of these Ky channels, was injected intracerebroventricularly in the rat brain, at a dose of 10 ng that did not disturb the rats' locomotor activity or drinking behaviour. In the first paradigm (odour-reward training), KTX improved learning but not information consolidation. Moreover, KTX increased the long-term retrieval of an odour-reward association tested by a reversal test 1 month after the odour-reward training. The second paradigm (successive odour-pair training) tested reference memory. The first session was an acquisition session where the rats learned a new odour-discrimination problem with the same procedure. The second was a retention session held 24 h later to test retrieval of the learned information. KTX injected before the acquisition or retention session improved performance, but no effect was found when KTX was injected immediately after acquisition. We showed that these effects were not due to the action of KTX on attention processes. Thus, these results suggest that the blockage of Kv1.1 or Kv1.3 channels by KTX facilitates cognitive processes as learning, in particular in a reference representation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:17:48