Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Erythromycin enhances oesophageal motility in patients with gastro-oesophageal reflux
Autore:
Chrysos, E; Tzovaras, G; Epanomeritakis, E; Tsiaoussis, J; Vrachasotakis, N; Vassilakis, JS; Xynos, E;
Indirizzi:
Univ Crete, Univ Hosp Heraklion, Dept Gen Surg, GR-71110 Heraklion, Crete,Greece Univ Crete Heraklion Crete Greece GR-71110 -71110 Heraklion, Crete,Greece
Titolo Testata:
ANZ journal of surgery
fascicolo: 2, volume: 71, anno: 2001,
pagine: 98 - 102
SICI:
1445-1433(200102)71:2<98:EEOMIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER ESOPHAGEAL SPHINCTER; GASTROESOPHAGEAL REFLUX; HEALTHY-SUBJECTS; DISEASE; SOLIDS;
Keywords:
erythromycin; gastro-oesophageal reflux; oesophageal motility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Xynos, E Univ Crete, Univ Hosp Heraklion, Dept Gen Surg, GR-71110 Heraklion, Crete,Greece Univ Crete Heraklion Crete Greece GR-71110 raklion, Crete,Greece
Citazione:
E. Chrysos et al., "Erythromycin enhances oesophageal motility in patients with gastro-oesophageal reflux", AUST NZ J S, 71(2), 2001, pp. 98-102

Abstract

Background: Intravenous (i.v.) erythromycin enhances gastric emptying and oesophageal motility in both healthy and disease situations, acting either as a motilin or acetylcholine agonist. The purpose of the present paper wasto investigate any possible effect of i.v. erythromycin on oesophageal motility in patients with gastro-oesophageal reflux (GOR). Methods: In 15 patients with GOR (proven on 24-h ambulatory oesophageal pHmeasurement), standard oesophageal manometry was performed after i.v. injection of placebo and 200 mg erythromycin, in a random blind fashion. Results: Erythromycin significantly increased lower oesophageal sphincter (LOS) pressure from 17 +/- 5 to 41 +/- 10 mmHg (P < 0.001), without affecting the postdeglutition relaxation of LOS. Erythromycin also increased the amplitude (from 79 +/- 34 to 97 +/- 40 mmHg; P < 0.001), duration (from 3.4 /- 0.6 to 3.8 +/- 0.6 s; P = 0.005), velocity (from 3.1 +/- 0.8 to 3.5 +/-1.15 cm/s; P = 0.0047) and strength (from 149 +/- 84 to 201 +/- 103 mmHg.s; P < 0.001) of peristalsis at 5 cm proximal to the LOS. Similarly, the drug increased the amplitude of peristalsis at 10 and 15 cm proximal to the LOS (from 70 +/- 39 to 77.4 +/- 37 mmHg; P = 0.049 and from 36 +/- 20 to 49 +/- 36 mmHg; P = 0.004, respectively) and the duration of peristalsis at thesame levels (from 3.1 +/- 0.6 to 3.3 +/- 0.5 s; P = 0.011, and from 2.7 +/- 0.6 to 3 +/- 0.5 s; P = 0.003, respectively). Conclusion: Intravenously administered erythromycin improves impaired oesophageal motility in patients with GOR. This observation might be of clinical use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:31:15