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Titolo:
Clinical long-term results of vascular prosthesis sealed with fragmented autologous adipose tissue
Autore:
Karube, N; Soma, T; Noishiki, Y; Yamazaki, I; Kosuge, T; Ichikawa, Y; Takanashi, Y;
Indirizzi:
Saiseikai Yokohama City Nanbu Hosp, Dept Cardiovasc Surg, Kohnan Ku, Yokohama, Kanagawa 2348503, Japan Saiseikai Yokohama City Nanbu Hosp Yokohama Kanagawa Japan 2348503 Japan Yokohama City Univ, Sch Med, Dept Surg 1, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan
Titolo Testata:
ARTIFICIAL ORGANS
fascicolo: 3, volume: 25, anno: 2001,
pagine: 218 - 222
SICI:
0160-564X(200103)25:3<218:CLROVP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
KNITTED DACRON; GRAFTS; ENDOTHELIUM; BYPASS;
Keywords:
vascular prosthesis; adipose tissue; lower extremity ischemia; tissue engineering; bypass reconstruction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Karube, N Saiseikai Yokohama City Nanbu Hosp, Dept Cardiovasc Surg, KohnanKu, 3-2-10 Kohnandai, Yokohama, Kanagawa 2348503, Japan Saiseikai YokohamaCity Nanbu Hosp 3-2-10 Kohnandai Yokohama Kanagawa Japan 2348503
Citazione:
N. Karube et al., "Clinical long-term results of vascular prosthesis sealed with fragmented autologous adipose tissue", ARTIF ORGAN, 25(3), 2001, pp. 218-222

Abstract

Tissue engineering can improve the former limitations of artificial organs. This article reports the long-term clinical results of grafts constructedwith fragmented autologous adipose tissue. We did a retrospective analysisof a series of 53 patients with lower leg ischemia that received 69 fragmented adipose tissue (FAT) grafts implantation at our institution. The mean follow-up period was 36.0 months. After 1, 2, 3. and 5 years, the primary potency sates were 85.3, 83.3, 73.8, and 67.7%, respectively. The lumen of occluded areas not only at anastomotic sites but also in areas far from the anastomotic sites was occupied by a thickened neointima, which had a great number of capillary blood vessels, elastic laminae, smooth muscle cells, fibroblasts, and collagen fibers. This type of intimal hyperplasia was a characteristic finding in the FAT grafts. From the results of this clinical trial, we conclude that the FAT grafts are acceptable as vascular prostheses for ischemic lower extremities. The intimal hyperplasia at sites far from the anastomotic lines suggested the possibility of neointima formation throughout the luminal surface of the grafts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 01:31:22