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Titolo:
Current concepts in tissue engineering technique for repair of cartilage defect
Autore:
Ochi, M; Uchio, Y; Tobita, M; Kuriwaka, M;
Indirizzi:
Shimane Med Univ, Dept Orthopaed, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 zumo, Shimane 6938501, Japan
Titolo Testata:
ARTIFICIAL ORGANS
fascicolo: 3, volume: 25, anno: 2001,
pagine: 172 - 179
SICI:
0160-564X(200103)25:3<172:CCITET>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN GEL; PROLIFERATION; KNEE; PHENOTYPE;
Keywords:
cartilage repair; tissue engineering; chondrocyte; culture; atelocollagen; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ochi, M Shimane Med Univ, Dept Orthopaed, 89-1 Enya Cho, Izumo, Shimane 6938501, Japan Shimane Med Univ 89-1 Enya Cho Izumo Shimane Japan 6938501 , Japan
Citazione:
M. Ochi et al., "Current concepts in tissue engineering technique for repair of cartilage defect", ARTIF ORGAN, 25(3), 2001, pp. 172-179

Abstract

Hunter's observation in 1743 that cartilage "once destroyed, is not repaired," has not essentially changed for 250 years. At present, there is no well-established procedure for the repair of cartilage defect with articular cartilage, which has the same biochemical and biomechanical properties as the surrounding normal intact cartilage. In 1994, transplantation of human autologous chondrocytes in suspension, as reported by Brittberg et al.: provided a potential procedure for articular cartilage repair. We have improved their procedure and developed a new technique which creates new cartilage-like tissue by cultivating autologous chondrocytes embedded in Atelo-collagen gel for 3 weeks before transplantation. These improvements maintained thechondrocyte phenotype, evenly distributed chondrocytes throughout the osteochondral defects, and decreased the risk of leakage of grafted chondrocytes into the defects. Good clinical results suggest that this technique should be a promising procedure for repairing articular cartilage defect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:04:52