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Titolo:
Automated synthesis and purification of [F-18]bromofluoromethane at high specific radioactivity
Autore:
Bergman, J; Eskola, O; Lehikoinen, P; Solin, O;
Indirizzi:
Abo Akad Univ, Turku PET Ctr, Accelerator Lab, FIN-20500 Turku, Finland Abo Akad Univ Turku Finland FIN-20500 ator Lab, FIN-20500 Turku, Finland Turku PET Ctr, Radiopharmaceut Chem Lab, FIN-20500 Turku, Finland Turku PET Ctr Turku Finland FIN-20500 Chem Lab, FIN-20500 Turku, Finland
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 6, volume: 54, anno: 2001,
pagine: 927 - 933
SICI:
0969-8043(200106)54:6<927:ASAPO[>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLISM; IODIDE; F-18;
Keywords:
[F-18]bromofluoromethane; specific radioactivity; LC-MS; F-18;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Solin, O Abo Akad Univ, Turku PET Ctr, Accelerator Lab, Porthaninkatu 3, FIN-20500 Turku, Finland Abo Akad Univ Porthaninkatu 3 Turku Finland FIN-20500 u, Finland
Citazione:
J. Bergman et al., "Automated synthesis and purification of [F-18]bromofluoromethane at high specific radioactivity", APPL RAD IS, 54(6), 2001, pp. 927-933

Abstract

[F-18]Bromofluoromethane was synthesised from dibromomethane by substitution of bromine with [F-18]fluoride. The synthesis and separation of the [F-18]bromofluoromethane were automated. [F-18]Bromofluoromethane was used to convert a phenolic and a thiophenolic precursor into a labelled ether and thioether, respectively. The specific radioactivity of these labelled products was determined with both high-performance liquid chromatography (with UV-absorbance detection) and liquid chromatography (with mass spectrometric detection). The median for the specific radioactivity, corrected at the end of radionuclide production, was 934 GBq/mu mol (range 40-9900 GBq/mu mol; n = 83). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:54:00