Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Importance of direct determination of amino acid co- and counter-transportstoichiometries
Autore:
Van Winkle, LJ;
Indirizzi:
Midwestern Univ, Dept Biochem, Downers Grove, IL 60515 USA Midwestern Univ Downers Grove IL USA 60515 m, Downers Grove, IL 60515 USA
Titolo Testata:
AMINO ACIDS
fascicolo: 2, volume: 20, anno: 2001,
pagine: 105 - 111
SICI:
0939-4451(2001)20:2<105:IODDOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE TRANSPORTER;
Keywords:
amino acids; kinetics; thermodynamics; transport; transporters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Van Winkle, LJ Midwestern Univ, Dept Biochem, 555 31st St, Downers Grove, IL 60515 USA Midwestern Univ 555 31st St Downers Grove IL USA 60515 USA
Citazione:
L.J. Van Winkle, "Importance of direct determination of amino acid co- and counter-transportstoichiometries", AMINO ACIDS, 20(2), 2001, pp. 105-111

Abstract

The stoichiometry of amino acid transport with co- or counter-substrates of a given system has been found to vary with the amino acid species. This phenomenon has been studied directly in only a few cases, however, by measuring the fluxes of the substrates simultaneously. More frequently, the apparent transport stoichiometries of single amino acid species with co- or counter-substrates are estimated indirectly by thermodynamic criteria or cooperative kinetic effects. Unfortunately the latter indirect measures of apparent stoichiometry often yield different results than direct measurement of simultaneous fluxes. These differences often cannot be explained by uncoupled transport of one of the co- or counter-substrates or by other characteristics of the transport process that would make the direct measurement of stoichiometry inaccurate. For these reasons, investigators are encouraged to measure the stoichiometry of transport directly by measuring simultaneous fluxes of co- and counter-substrates. Indirect measures of apparent stoichiometry may, however, reflect important details of a transport mechanism even if they are inconsistent with the actual stoichiometry of transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:52:32