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Titolo:
A case of partial carnitine palmitoyltransferase deficiency in a patient undergoing chronic hemodialysis
Autore:
Soejima, A; Waku, M; Kamiya, Y; Kaneda, F; Ishizuka, S; Nagasawa, T;
Indirizzi:
Kyorin Univ, Sch Med, Dept Internal Med 1, Mitaka, Tokyo 1818611, Japan Kyorin Univ Mitaka Tokyo Japan 1818611 ed 1, Mitaka, Tokyo 1818611, Japan
Titolo Testata:
AMERICAN JOURNAL OF NEPHROLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 63 - 65
SICI:
0250-8095(200101/02)21:1<63:ACOPCP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE; OXIDATION;
Keywords:
uremic myopathy; carnitine; carnitine palmitoyltransferase; hemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Soejima, A Kyorin Univ, Sch Med, Dept Internal Med 1, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan Kyorin Univ 6-20-2 Shinkawa Mitaka Tokyo Japan 1818611 1, Japan
Citazione:
A. Soejima et al., "A case of partial carnitine palmitoyltransferase deficiency in a patient undergoing chronic hemodialysis", AM J NEPHR, 21(1), 2001, pp. 63-65

Abstract

A 71-year-old male undergoing hemodialysis for ch ron ic renal failure presented with proximal muscle weakness. He had normal levels of serum creatine phosphokinase. The results of nerve conduction velocity studies and a needle-exploration electromyogram were normal. Ultrasonography revealed adenomatous enlargement of the parathyroid glands, and he had marked elevation ofthe serum parathormone level. The level of serum free carnitine before hemodialysis was significantly lower than normal, while the acyl/free ratio was high. However, the muscle carnitine content was within the normal range. Interestingly, partial inactivation of carnitine palmitoyltransferase activity in the muscle was observed in association with the elevation of the serum parathormone level. Uremic myopathy in this case may be caused not only by abnormal carnitine metabolism but could also be attributable to the partial carnitine palmitoyltransferase deficiency associated with secondary hyperparathyroidism. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 19:26:35