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Titolo:
Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study
Autore:
Linneberg, A; Nielsen, NH; Madsen, F; Frolund, L; Dirksen, A; Jorgensen, T;
Indirizzi:
Glostrup Cty Hosp, Ctr Prevent Med, Dept Internal Med M, DK-2600 Glostrup,Denmark Glostrup Cty Hosp Glostrup Denmark DK-2600 d M, DK-2600 Glostrup,Denmark Gentofte Hosp, Dept Dermatol, Copenhagen, Denmark Gentofte Hosp Copenhagen Denmark sp, Dept Dermatol, Copenhagen, Denmark Frederiksberg Hosp, Dept Internal Med B, Frederiksberg, Denmark Frederiksberg Hosp Frederiksberg Denmark Med B, Frederiksberg, Denmark Univ Copenhagen, Gentofte Hosp, Dept Resp Med Y, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark
Titolo Testata:
ALLERGY
fascicolo: 4, volume: 56, anno: 2001,
pagine: 328 - 332
SICI:
0105-4538(200104)56:4<328:SATDOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; SERUM IGE; RESPIRATORY SYMPTOMS; GLOSTRUP ALLERGY; COHORT; ATOPY; AGE; SEX; PREVALENCE; DENMARK;
Keywords:
adult; epidemiology; respiratory hypersensitivity; skin prick test; smoking; specific IgE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Linneberg, A Glostrup Cty Hosp, Ctr Prevent Med, Dept Internal Med M, 57 Ndr Ringvej,Entrance 8,7th Floor, DK-2600 Glostrup, Denmark Glostrup Cty Hosp 57 Ndr Ringvej,Entrance 8,7th Floor Glostrup Denmark DK-2600
Citazione:
A. Linneberg et al., "Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study", ALLERGY, 56(4), 2001, pp. 328-332

Abstract

Background: Several cross-sectional population-based studies have reporteda negative association between smoking and allergic sensitization to aeroallergens. In a prospective study, we investigated the association between smoking and the development (incidence) of allergic sensitization as reflected by skin prick test (SPT) positivity and specific IgE positivity. Methods: Participants in a population-based study of 15-69-year-olds in 1990 were invited to a follow-up in 1998. Thus, SPT positivity and specific IgE positivity to common aeroallergens were assessed in 734 subjects (participation rate: 69.0%) on two occasions 8 years apart. The effect of smoking on the development of allergic sensitization was adjusted for potential confounders such as age, sex, family history of hay fever, educational level, and total IgE. Results: During the follow-up period, 58 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. The risk of developing SPT positivity (adjusted odds ratio: 0.45, 95% CI 0.21-0.98) and specific IgE positivity (adjusted odds ratio: 0.62, 95% CI 0.26-1.49) was lower among sustained smokers than never-smokers. Conclusions: In this adult population, sustained smoking was negatively associated with the development of allergic sensitization to aeroallergens during an 8-year follow-up. This negative association, if real, might be due to an immunosuppressive effect of smoking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:26:30