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Titolo:
Carbohydrate structures of haptoglobin in sera of healthy people and a patient with congenital disorder of glycosylation
Autore:
Ferens-Sieczkowska, M; Olczak, M;
Indirizzi:
Wroclaw Med Univ, Dept Chem & Immunochem, PL-50345 Wroclaw, Poland WroclawMed Univ Wroclaw Poland PL-50345 ochem, PL-50345 Wroclaw, Poland Univ Wroclaw, Inst Biochem & Mol Biol, PL-50137 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50137 Mol Biol, PL-50137 Wroclaw, Poland
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
fascicolo: 1-2, volume: 56, anno: 2001,
pagine: 122 - 131
SICI:
0939-5075(200101/02)56:1-2<122:CSOHIS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT GLYCOPROTEIN SYNDROME; INFLAMMATION-INDUCED EXPRESSION; SYNDROME TYPE-I; ALPHA(1)-ACID GLYCOPROTEIN; PROTEIN GLYCOSYLATION; ALTERED GLYCOSYLATION; SIALYL LEWIS(X); OLIGOSACCHARIDES; CANCER; TRANSFERRIN;
Keywords:
haptoglobin; glycosylation; congenital disorder of glycosylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ferens-Sieczkowska, M Wroclaw Med Univ, Dept Chem & Immunochem, Bujwida 44A, PL-50345 Wroclaw, Poland Wroclaw Med Univ Bujwida 44A Wroclaw Poland PL-50345
Citazione:
M. Ferens-Sieczkowska e M. Olczak, "Carbohydrate structures of haptoglobin in sera of healthy people and a patient with congenital disorder of glycosylation", Z NATURFO C, 56(1-2), 2001, pp. 122-131

Abstract

Haptoglobin is one of acute phase glycoproteins often used as markers in glycopathology studies. In this work the oligosaccharide structures of haptoglobin from 'healthy' subjects have been studied in detail, taking into consideration the possible dependence of glycosylation on the phenotype. About75% of charged haptoglobin glycans were of biantennary complex structure, and some of them lacked one terminal sialic acid molecule. Triantennary structures made up almost 25% of the charged glycans pool, and highly branchedtetrasialylated oligosaccharides did not exceed 1%. The main difference between haptoglobin derived from the sample of pooled 44 sera and from the 2-2 phenotype individual concerned the relative content of trisialylated oligosaccharide with one 2-3 linked sialic acid residue. The oligosaccharide profile of haptoglobin derived from serum of a patient suffering from congenital disorder of glycosylation was compared to 'healthy' controls. It was shown, that four main glycans are identical in patient and 'normal' haptoglobins. Some alterations were found in the relative content of mono-. bi-, andtrisialylated glycans as well as in the appearance of some tracery abundant oligosaccharides in haptoglobin of the patient with congenital disorder of glycosylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:40:52