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Titolo:
Association of SV40 with human tumours
Autore:
Jasani, B; Cristaudo, A; Emri, SA; Gazdar, AF; Gibbs, A; Krynska, B; Miller, C; Mutti, L; Radu, C; Tognon, M; Procopio, A;
Indirizzi:
Univ Wales Coll Med, Dept Pathol, Immunol & Mol Pathol Unit, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF14 4XN CF14 4XN, S Glam, Wales Univ Pisa, S Chiara Hosp, Div Occupat Prevent Med, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 iv Occupat Prevent Med, I-56100 Pisa, Italy Univ Hacettepe, Sch Med, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 , Sch Med, TR-06100 Ankara, Turkey Univ Texas, SW Med Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 iv Texas, SW Med Ctr, Dallas, TX 75235 USA MC Hahnemann Univ, Ctr Canc, Philadelphia, PA 19102 USA MC Hahnemann UnivPhiladelphia PA USA 19102 c, Philadelphia, PA 19102 USA Univ Calif Los Angeles, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA Univ Calif Los Angeles Los Angeles CA USA 90048 Los Angeles, CA 90048 USA Univ Ferrara, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100Univ Ferrara, I-44100 Ferrara, Italy Univ Chieti, Chieti, Italy Univ Chieti Chieti ItalyUniv Chieti, Chieti, Italy
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 49 - 61
SICI:
1044-579X(200102)11:1<49:AOSWHT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE-T-ANTIGEN; HUMAN PLEURAL MESOTHELIOMA; HUMAN-BRAIN-TUMORS; HUMAN-MALIGNANT MESOTHELIOMAS; PERIPHERAL-BLOOD CELLS; 40-LIKE DNA-SEQUENCES; TRANSGENIC MICE; SIMIAN-VIRUS-40 SEQUENCES; SV40-LIKE SEQUENCES; HUMAN FIBROBLASTS;
Keywords:
SV40; human tumour; cancer; PCR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Jasani, B Univ Wales Coll Med, Dept Pathol, Immunol & Mol Pathol Unit, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF144XN S Glam, Wales
Citazione:
B. Jasani et al., "Association of SV40 with human tumours", SEM CANC B, 11(1), 2001, pp. 49-61

Abstract

SV40 was discovered as a contaminant of poliovirus vaccines that were inadvertently administered to millions of people in Europe and the United States between 1955 and 1963. Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. The possibility that SV40 might cause tumours in humans thus became a subject of scientific and public interest and scrutiny. However, largely, due to a lack of significant epidemiological evidence interest in assessing SV40'spotential carcinogenic role in humans diminished. Recently, many laboratories have reported the presence of SV40-like DNA in a high proportion of human mesotheliomas, ependymomas and osteosarcoma (the three main types of tumours caused by virus in hamsters), renewing the question whether SV40 mightbe a human tumour virus. Molecular data from these studies are reviewed tore-evaluate the potential role of SV40 as a human carcinogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:01:49