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Titolo:
The role of the SV40ST antigen in cell growth promotion and transformation
Autore:
Rundell, K; Parakati, R;
Indirizzi:
Northwestern Univ, Dept Immunol Microbiol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 l Microbiol, Chicago, IL 60611 USA Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA Robert H Lurie Comprehens Canc Ctr Chicago IL USA 60611 ago, IL 60611 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 5 - 13
SICI:
1044-579X(200102)11:1<5:TROTSA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-T-ANTIGEN; SIMIAN-VIRUS-40 SMALL-T; VIRUS-40 LARGE-T; PROTEIN PHOSPHATASE 2A; LARGE TUMOR-ANTIGEN; DNA-REPLICATION INVITRO; AMINO-TERMINAL DOMAIN; EARLY MESSENGER-RNA; SIMIAN VIRUS-40; INDEPENDENT EXPRESSION;
Keywords:
growth promotion; transformation; human fibroblasts; small-t antigen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Rundell, K Northwestern Univ, Dept Immunol Microbiol, 320 E Super Ave, Chicago, IL 60611 USA Northwestern Univ 320 E Super Ave Chicago IL USA 60611 0611 USA
Citazione:
K. Rundell e R. Parakati, "The role of the SV40ST antigen in cell growth promotion and transformation", SEM CANC B, 11(1), 2001, pp. 5-13

Abstract

The simian virus 40 small-t (ST) antigen plays a key role ir;! permissive and nonpermissive infections, increasing virus yields in lytic cycles of primate cells and enhancing the ability of large-T(LT) to transform rodent oreven human cells. In the absence of ST, tumors in rodent model systems appear primarily in lymphoid and other proliferative tissues and transformation is reduced in several in vitro systems. The functions of ST largely reflect its binding and inhibition of protein phosphatase 2A, although a recently described dnaJ domain also contributes to its biology, The dnaJ domain ispresent in LT and a third early gene product, the 17kT protein, for which a potential role in transformation deserves further evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:01:29