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Titolo:
Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons
Autore:
Kohara, K; Kitamura, A; Morishima, M; Tsumoto, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Biomed Res Ctr, Div Neurophysiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 physiol, Suita, Osaka 5650871, Japan Japan Sci & Technol Corp, CREST, Kawaguchi 3320012, Japan Japan Sci & Technol Corp Kawaguchi Japan 3320012 awaguchi 3320012, Japan
Titolo Testata:
SCIENCE
fascicolo: 5512, volume: 291, anno: 2001,
pagine: 2419 - 2423
SICI:
0036-8075(20010323)291:5512<2419:ATOBNF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; PRIMARY SENSORY NEURONS; HIPPOCAMPAL-NEURONS; VISUAL-CORTEX; ANTEROGRADE TRANSPORT; MESSENGER-RNA; PLASTICITY; BDNF; CNS; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tsumoto, T Osaka Univ, Grad Sch Med, Biomed Res Ctr, Div Neurophysiol, 2-2Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita OsakaJapan 5650871 50871, Japan
Citazione:
K. Kohara et al., "Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons", SCIENCE, 291(5512), 2001, pp. 2419-2423

Abstract

Neurotrophins such as brain-derived neurotrophic factor (BDNF) are thoughtto be transferred from post- to presynaptic neurons and to be involved in the formation and plasticity of neural circuits, However, direct evidence for a transneuronal transfer of BDNF and its relation to neuronal activity remains elusive, We simultaneously injected complementary DNAs of green fluorescent protein (GFP)-tagged BDNF and red fluorescence protein into the nucleus of single neurons and visualized expression, localization, and transport of BDNF in living neurons. Fluorescent puncta representing BDNF moved inaxons in the anterograde direction, though some moved retrogradely, and transferred to postsynaptic neurons in an activity-dependent manner.

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Documento generato il 25/11/20 alle ore 18:39:03