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Titolo:
Comparing the adrenaline-Pirquet test with international PPD tuberculin tests
Autore:
Jentoft, HF; Omenaas, E; Eide, GE; Gulsvik, A;
Indirizzi:
Haukeland Univ Hosp, Dept Thorac Med, N-5021 Bergen, Norway Haukeland UnivHosp Bergen Norway N-5021 orac Med, N-5021 Bergen, Norway Haukeland Univ Hosp, Clin Res Ctr, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 Res Ctr, N-5021 Bergen, Norway Univ Bergen, Inst Med, Bergen, Norway Univ Bergen Bergen NorwayUniv Bergen, Inst Med, Bergen, Norway Univ Bergen, Sect Med Stat, Bergen, Norway Univ Bergen Bergen NorwayUniv Bergen, Sect Med Stat, Bergen, Norway
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 3, volume: 95, anno: 2001,
pagine: 205 - 211
SICI:
0954-6111(200103)95:3<205:CTATWI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-BOVIS; BCG; VARIABILITY; MPB64;
Keywords:
tuberculins; cut-off points; ROC curves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Jentoft, HF Haukeland Univ Hosp, Dept Thorac Med, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 5021 Bergen, Norway
Citazione:
H.F. Jentoft et al., "Comparing the adrenaline-Pirquet test with international PPD tuberculin tests", RESP MED, 95(3), 2001, pp. 205-211

Abstract

Several tuberculins, strengths and setting methods are in everyday use. Wewanted to compare the Norwegian reference adrenaline-Pirquet test with theinternationally recommended Mantoux PPD test and Rhoditest. In responders of a random sample of young adults, with randomization of test subjects, we intra-individually compared the adrenaline-Pirquet (aP) test with Norwegian-produced synthetic medium tuberculin (SMT) with either theMantoux test with PPD 2 tuberculin units (TU) (M2), the Mantoux-PPD 5 TU (M5) or the PPD 2 TU-Rhoditest (Rh). The criteria for a positive reaction were greater than or equal to 4 mm for the aP test, greater than or equal to 10 mm for the M2 test, greater than or equal to6 mm for the M5 test and greater than or equal to2 mm for the Rh test. Strongly positive reactions weredefined as aP test greater than or equal to 10 mm and M2/M5 test greater than or equal to 15 mm. One of the tuberculin tests was positive while the comparison test was negative in 14% of the M2 test group (n = 236), 15% in the M5 test group (n = 162) and 20% in the Rh test group (n = 187). The three PPD tests had positive reactions 3-10 times as often, with a simultaneous negative aP test, than vice versa. Strongly positive reactions occurred in 7% of the aP tests (greater than or equal to 10 mm), 32% of the M2 tests (greater than or equal to 15 mm) and in 41% of the M5 tests (greater than or equal to 15 mm). Receiver operating characteristic (ROC) curves gave the best agreement, with aPtest greater than or equal to3 mm compared with the M2 and the Rh tests. Regression equations are presented for transformations of the Norwegian reference method of adrenaline-Pirquet results to internationally recommended PPD tests. The international recommendations, globalization in general and the skill of Norwegian public health nurses in performing intra-dermal BCG suggest a future shift to the PPD 2 TU Mantoux test in Norway. Due to the lack of sensitivity and specificity of all tuberculin tests they might be used in targeted tuberculin testing and not as a general screening procedure in a low-incidence tuberculosis area with BCG-vaccinated inhabitants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:12:12