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Titolo:
Role of nitric oxide on atrial natriuretic peptide release induced by angiotensin II in superfused rat atrial tissue
Autore:
Soualmia, H; Barthelemy, C; Eurin, J; Masson, F; Carayon, A;
Indirizzi:
Fac Med Pitie Salpetriere, Serv Biochim, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 chim, F-75634 Paris 13, France
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 3, volume: 98, anno: 2001,
pagine: 105 - 110
SICI:
0167-0115(20010420)98:3<105:RONOOA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETION; CELLS; CYCLASE; ESTER;
Keywords:
cardiac hormone; vasoconstrictor peptide; endothelium-derived relaxing factor; guanylate cyclase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Soualmia, H Fac Med Pitie Salpetriere, Serv Biochim, 91 Bd Hop, F-75634 Paris 13, France Fac Med Pitie Salpetriere 91 Bd Hop Paris France 13 3, France
Citazione:
H. Soualmia et al., "Role of nitric oxide on atrial natriuretic peptide release induced by angiotensin II in superfused rat atrial tissue", REGUL PEPT, 98(3), 2001, pp. 105-110

Abstract

The present study investigated the role of nitric oxide (NO) on atrial natriuretic peptide (ANP) release stimulated by angiotensin II (Ang II) (10(-7) M) in superfused sliced rat atrial tissue. The use of N-G-nitro-L arginine methyl ester (L-NAME) at 10(-4) M, an inhibitor of nitric oxide synthase did not modify basal ANP release. In presence of Ang II (10(-7) M), we observed that L-NAME enhanced ANP secretion induced by Ang II. Furthermore, cGMP levels increased significantly in the presence of Ang II and was attenuated by L-NAME. On the other hand, the perfusion of 8 bromo-cGMP (10(-5) M) with Ang II reduced the effect of this octapeptide on ANP secretion. Secondly, we evaluated the effect of authentic NO on ANP release and observed thatperfusion of NO reduced significantly the effect of Ang II on ANP release. We propose that the effect of Ang II on ANP secretion was modulated by NO likely via cGMP pathway. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:48:44