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Titolo:
Nicotine-induced enhancements in the five-choice serial reaction time taskin rats are strain-dependent
Autore:
Mirza, NR; Bright, JL;
Indirizzi:
Dept Neuropharmacol, Winnersh RG41 5UA, Wokingham, England Dept Neuropharmacol Winnersh Wokingham England RG41 5UA okingham, England NeuroSearch AS, DK-2750 Ballerup, Denmark NeuroSearch AS Ballerup Denmark DK-2750 ch AS, DK-2750 Ballerup, Denmark
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 154, anno: 2001,
pagine: 8 - 12
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED ATTENTION; PREPULSE INHIBITION; STARTLE; DRUGS;
Keywords:
nicotine; attention; rat; strain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Mirza, NR Dept Neuropharmacol, Oakdene Court,613 Reading Rd, Winnersh RG415UA, Wokingham, England Dept Neuropharmacol Oakdene Court,613 Reading Rd Winnersh Wokingham England RG41 5UA
Citazione:
N.R. Mirza e J.L. Bright, "Nicotine-induced enhancements in the five-choice serial reaction time taskin rats are strain-dependent", PSYCHOPHAR, 154(1), 2001, pp. 8-12

Abstract

Rationale: Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, wesurmised that nicotine would only improve performance in this strain. Methods: Rats were placed in operant chambers 10 min after nicotine treatment (0.001-0.2 mg/kg). Results: Nicotine dose-dependently increased correct responses only in SD rats (similar to 20% at the highest dose). By contrast, nicotine dose-dependently increased omission errors and reduced trials completed in both strains of rat, and dose-dependently reduced tray responses in SD rats. Conclusion: The magnitude of improvement in accuracy seen with nicotine in SD rats is greater than previously demonstrated using lesion or parametric manipulation models in other strains of rat in this test of attention. Although this suggests that the SD strain may be a useful "tool" for future studies, other task parameters, such as stimulus duration, may have to be optimum to demonstrate the magnitude of improvement observed presently.

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Documento generato il 23/01/20 alle ore 18:26:00