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Titolo:
Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence
Autore:
Mulchahey, JJ; Ekhator, NN; Zhang, H; Kasckow, JW; Baker, DG; Geracioti, TD;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 sychiat, Cincinnati, OH 45267 USA Vet Affairs Med Ctr, Psychiat Serv, Cincinnati, OH 45220 USA Vet Affairs Med Ctr Cincinnati OH USA 45220 erv, Cincinnati, OH 45220 USA
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 3, volume: 26, anno: 2001,
pagine: 273 - 285
SICI:
0306-4530(200104)26:3<273:CFAPTL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; MIDDLE-AGED MEN; CIGARETTE-SMOKING; HEALTHY-VOLUNTEERS; VIOLENT OFFENDERS; BINDING GLOBULIN; SEX-HORMONES; FIRE SETTERS; REPRODUCTION; STEROIDS;
Keywords:
androgens; cerebrospinal fluid (CSF); nicotine; post-traumatic stress disorder (PTSD); smoking; testosterone; tobacco dependence; corticotropin releasing hormone (CRH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mulchahey, JJ Univ Cincinnati, Coll Med, Dept Psychiat, 231 Albert Sabin Way, Cincinnati, OH 45267 USA Univ Cincinnati 231 Albert Sabin Way Cincinnati OH USA 45267
Citazione:
J.J. Mulchahey et al., "Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence", PSYCHONEURO, 26(3), 2001, pp. 273-285

Abstract

Background: Little is known about the relationship between endogenous central nervous system (CNS) testosterone and any psychiatric syndrome. The goal of this study was to screen for potential abnormalities in CNS testosterone levels in patients with post-traumatic stress disorder (PTSD) and/or tobacco dependence. Methods: We sampled cerebrospinal fluid (CSF) via a subarachnoid catheter over six hours and determined hourly basal CSF concentrations of testosterone in 11 combat veterans with PTSD and 12 normal volunteers. Smokers were abstinent for 11-17 h. Testosterone in CSF and matching plasma samples was assayed by radioimmunoassay. Results: A factor analysis for effects of PTSD status, smoking status and sample time revealed significant effects of PTSD or smoking status, but nottime, on CSF testosterone. CSF testosterone levels were lower in individuals with PTSD as compared with normal volunteers. When divided by smoking status, abstinent smokers had mean CSF testosterone levels higher than those of non-smokers. A similar analysis of plasma testosterone revealed no significant effects of any factor on plasma testosterone. Conclusions: These results indicate that CSF testosterone is significantlyinfluenced by PTSD and smoking status. The exposure of the brain to altered levels of testosterone in smokers and patients with PTSD may have pathophysiologic significance in these conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 25/01/20 alle ore 18:51:44