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Titolo:
Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder
Autore:
Deicken, RF; Eliaz, Y; Feiwell, R; Schuff, N;
Indirizzi:
Vet Affairs Med Ctr, Magnet Resonance Unit, San Francisco, CA 94121 USA Vet Affairs Med Ctr San Francisco CA USA 94121 an Francisco, CA 94121 USA Vet Affairs Med Ctr, Psychiat Serv, San Francisco, CA 94121 USA Vet Affairs Med Ctr San Francisco CA USA 94121 an Francisco, CA 94121 USA Univ Calif San Francisco, Sch Med, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 106, anno: 2001,
pagine: 35 - 45
SICI:
0925-4927(20010228)106:1<35:ITNIMP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; OBSESSIVE-COMPULSIVE DISORDER; CHOLINE-CONTAINING COMPOUNDS; LOCALIZED PROTON MRS; HUMAN BRAIN; ACETYL-ASPARTATE; MOOD DISORDERS; NEUROPSYCHIATRIC DISORDERS; ALZHEIMER-DISEASE; VIVO;
Keywords:
bipolar disorder; thalamus; magnetic resonance spectroscopy; magnetic resonance imaging; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Deicken, RF Vet Affairs Med Ctr, Magnet Resonance Unit, 4150 Clement St, San Francisco, CA 94121 USA Vet Affairs Med Ctr 4150 Clement St San Francisco CA USA 94121
Citazione:
R.F. Deicken et al., "Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder", PSYCH RES-N, 106(1), 2001, pp. 35-45

Abstract

N-Acetylaspartate (NAA) in the anterior and mediodorsal thalamic regions was measured using proton magnetic resonance spectroscopic imaging (H-1-MRSI) in 15 euthymic male patients with familial bipolar I disorder and compared to values in 15 male control subjects to determine if there was evidence for altered neuronal/axonal integrity. MRI tissue segmentation methods werealso utilized to obtain tissue-contribution estimates for each MRSI voxel. Relative to the comparison group, the patients with bipolar I disorder demonstrated significantly higher NAA and creatine in both the right and left thalamus. NAA was also significantly higher in the left thalamus compared to the right in both bipolar I patients and controls. There were no group orlateralized differences in the percentages of different tissue types within the MRSI voxels. suggesting that the thalamic NAA and creatine alterations were not an artifact of variations in tissue type percentages in the MRSIvoxels. There was also no significant association between NAA or creatine and illness duration. The findings of increased thalamic NAA bilaterally may represent neuronal hypertrophy or hyperplasia, reduced glial cell density, or abnormal synaptic and dendritic pruning. Increased thalamic creatine bilaterally may represent altered cellular energy metabolism and is consistent with prior studies demonstrating changes in thalamic metabolism in mood disorders. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:38:13