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Titolo:
Cellular and synaptic adaptations mediating opioid dependence
Autore:
Williams, JT; Christie, MJ; Manzoni, O;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 rmacol, Sydney, NSW 2006, Australia Univ Sydney, Med Fdn, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ed Fdn, Sydney, NSW 2006, Australia CNRS, Unite Propre Rech 9023, Montpellier, France CNRS Montpellier France RS, Unite Propre Rech 9023, Montpellier, France
Titolo Testata:
PHYSIOLOGICAL REVIEWS
fascicolo: 1, volume: 81, anno: 2001,
pagine: 299 - 343
SICI:
0031-9333(200101)81:1<299:CASAMO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; LOCUS-COERULEUS NEURONS; LONG-TERM POTENTIATION; PERIAQUEDUCTAL GRAY NEURONS; MESOLIMBIC DOPAMINE SYSTEM; CHRONIC MORPHINE TREATMENT; SUBSTANTIA-GELATINOSA NEURONS; ACTIVATED PROTEIN-KINASE; RECEPTOR MESSENGER-RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
545
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, JT Oregon Hlth Sci Univ, Vollum Inst, 3181 SW Sam Jackson Pk Rd,Portland, OR97201 USA Oregon Hlth Sci Univ 3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
J.T. Williams et al., "Cellular and synaptic adaptations mediating opioid dependence", PHYSIOL REV, 81(1), 2001, pp. 299-343

Abstract

Although opioids are highly effective for the treatment of pain, they are also known to be intensely addictive. There has been a massive research investment in the development of opioid analgesics, resulting in a plethora ofcompounds with varying affinity and efficacy at all the known opioid receptor subtypes. Although compounds of extremely high potency have been produced, the problem of tolerance to and dependence on these agonists persists. This review centers on the adaptive changes in cellular and synaptic function induced by chronic morphine treatment. The initial steps of opioid action are mediated through the activation of G protein-linked receptors. As is true for all G protein-linked receptors, opioid receptors activate and regulate multiple second messenger pathways associated with effector coupling, receptor trafficking, and nuclear signaling. These events are critical for understanding the early events leading to nonassociative tolerance and dependence. Equally important are associative and network changes that affect neurons that do not have opioid receptors but that are indirectly altered byopioid-sensitive cells. Finally, opioids and other drugs of abuse have some common cellular and anatomical pathways. The characterization of common pathways affected by different drugs, particularly after repeated treatment,is important in the understanding of drug abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:05:44