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Titolo:
Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine
Autore:
Hemmeter, U; Annen, B; Bischof, R; Bruderlin, U; Hatzinger, M; Rose, U; Holsboer-Trachsler, E;
Indirizzi:
Psychiat Univ Hosp Basle, Dept Depress Res Sleep Med & Neurophysiol, Basel, Switzerland Psychiat Univ Hosp Basle Basel Switzerland ophysiol, Basel, Switzerland
Titolo Testata:
PHARMACOPSYCHIATRY
fascicolo: 2, volume: 34, anno: 2001,
pagine: 50 - 59
SICI:
0176-3679(200103)34:2<50:PEOAGB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; SLEEP EEG; DOUBLE-BLIND; ENDOGENOUS-DEPRESSION; NOCTURNAL SECRETION; HORMONE-SECRETION; EXTRACT EGB-761; GROWTH-HORMONE; ALZHEIMER-TYPE; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Hemmeter, U Univ Marburg, Klin Psychiat & Psychotherapie, Zentrum Nervenheilkunde, Rudolph Bultmann Str 8, D-30533 Marburg, Germany Univ Marburg Rudolph Bultmann Str 8 Marburg Germany D-30533 y
Citazione:
U. Hemmeter et al., "Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine", PHARMACOPS, 34(2), 2001, pp. 50-59

Abstract

Sleep disturbance and cognitive impairment are frequent complaints of depressed patients under standard antidepressant medication. Therefore, additional therapies are required which specifically focus on the improvement of these deficits without exerting major side effects. Ginkgo biloba extract (EGb) has been shown to improve cognitive abilities in elderly subjects and in patients with disorders of the dementia spectrum. Animal studies surmise that EGb may reduce CRH activity, which is substantially related to depressive mood and behavior, predominantly cognition and sleep. An open non-randomized pilot study has been conducted to investigate the effects of ginkgo biloba extract (EGb Li 1370) on cognitive performance and sleep regulation in depressed inpatients, 16 patients were treated with a trimipramine (T)-monotherapy (200 mg) for six weeks. In eight of the 16 patients, an adjunct EGb therapy (240 mg/d) was applied for four weeks after a baseline week, theother eight patients remained on trimipramine monotherapy (200 mg) during the entire study. Polysomnography, cognitive psychomotor performance and psychopathology were assessed at baseline, after short-term and long-term adjunct EGb treatment, and after one week of ginkgo discontinuation (at the respective evaluation times in the eight patients on T-monotherapy). This report focuses on the results of EGb on sleep EEG pattern. EGb significantly improved sleep pattern by an increase of sleep efficiency and a reduction ofawakenings. In addition, sleep stage 1 and REM-density were reduced, whilestage 2 was increased. Non-REM sleep, predominantly slow wave sleep in thefirst sleep cycle, was significantly enhanced compared to trimipramine monotherapy. Discontinuation of EGb reversed most of these effects. Based on the animal data, these results suggest that EGb may improve sleep continuityand enhance Non-REM sleep due to a weakening of tonic CRH-activity. The compensation of the deficient Non-REM component in depression by the EGb application may provide a new additional treatment strategy, especially in the treatment of the depressive syndrome with sleep disturbance.

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Documento generato il 18/01/20 alle ore 21:33:35