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Titolo:
Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: A possible role in synovial proliferation
Autore:
Nakashima, M; Uchida, T; Tsukazaki, T; Hamanaka, Y; Fukuda, E; Ito, M; Sekine, I;
Indirizzi:
Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Tissue & Histopathol Sect,Div Sci Data Registry, Nagasaki 8528523, Japan Nagasaki Univ Nagasaki Japan 8528523 a Registry, Nagasaki 8528523, Japan Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Dept Mol Pathol, Nagasaki 8528523, Japan Nagasaki Univ Nagasaki Japan 8528523 Mol Pathol, Nagasaki 8528523, Japan Nagasaki Univ, Sch Med, Dept Orthoped Surg, Nagasaki 8528523, Japan Nagasaki Univ Nagasaki Japan 8528523 hoped Surg, Nagasaki 8528523, Japan Nagasaki Univ, Sch Med, Dept Anat 1, Nagasaki 8528523, Japan Nagasaki Univ Nagasaki Japan 8528523 ept Anat 1, Nagasaki 8528523, Japan Natl Nagasaki Cent Hosp, Dept Pathol, Nagasaki, Japan Natl Nagasaki Cent Hosp Nagasaki Japan sp, Dept Pathol, Nagasaki, Japan
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 2, volume: 197, anno: 2001,
pagine: 101 - 107
SICI:
0344-0338(2001)197:2<101:EOTKRT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; BLOOD-VESSEL FORMATION; ENDOTHELIAL-CELLS; GROWTH-FACTOR; ANGIOGENESIS; TEK; ANGIOPOIETIN-1; VASCULOGENESIS; LOCALIZATION; REVEAL;
Keywords:
Tie-1; Tie-2; angiogenesis; synovium; giant cell tumor of tendon sheath;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakashima, M Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Tissue & Histopathol Sect,Div Sci Data Registry, 1-12-4 Sakamoto, Nagasaki 8528523, Japan Nagasaki Univ 1-12-4 Sakamoto Nagasaki Japan 8528523 , Japan
Citazione:
M. Nakashima et al., "Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: A possible role in synovial proliferation", PATH RES PR, 197(2), 2001, pp. 101-107

Abstract

We have recently demonstrated that Tie-1 and Tie-2 are expressed in synovial cells from rheumatoid arthritis (RA). To elucidate the possible involvement of Tie receptors in synovial proliferation, we analyzed their expression by immunostaining in five cases of giant cell tumor of tendon sheath (GCTTS), which represents a proliferating lesion of synovial cells. Strong immunoreactivity for both Tie-1 and Tie-2, regardless of the individual patient's profile, was observed in all cases of GCTTS. Six sets of double immunohistochemical stainings for Tie-1/Tie-2 and fibronectin, CD68, or CD34 were carried out to determine the phenotype of Tie-1 and Tie-2-positive tumor components. In these studies, both Tie-1 and Tie-2 immunoreactivity were widely observed in the fibronectin-positive fibroblastic and the CD68-positive histiocytic mononuclear cells, as well as in the osteoclast-like giant cells. In tumor vasculature, Tie receptors were expressed in the CD34-positive endothelial cells possessing proliferating cell nuclear antigen (PCNA) immunoreactivity. We also evaluated the correlation of Tie-1/Tie-2 expression and proliferating cells in GCTTS by using double staining of Tie-1/Tie-2 together with PCNA. Overexpression of PCNA immunoreactivity was frequently found in Tie receptors-positive cells with no obvious differences in the expression pattern of Tie-1 and Tie-2. These findings suggest the possible involvement of Tie receptors in the pathogenesis of GCTTS other than solely via their involvement in angiogenesis and subsequent vascularization. It was demonstrated that Tie-2 immunoreactivity was restricted to the fibroblastic, but not histiocytic, phenotype in RA synovium, suggesting different regulatory control of Tie-2 expression in GCTTS and RA synovium. Overexpression of Tie receptors in GCTTS may imply a biological role for these receptors in synovial proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:19:38