Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immune responses to multiple antigen peptides containing T and B epitopes from Plasmodium falciparum circumsporozoite protein of Brazilian individuals naturally exposed to malaria
Autore:
Avila, SLM; Goldberg, AC; Arruk, VG; Marin, ML; Guilherme, L; Kalil, J; Ferreira, AW;
Indirizzi:
Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, BR-05403140 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05403140 BC05403140 Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Inst Heart, InCor, BR-05508 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508 Cor, BR-05508 Sao Paulo, Brazil
Titolo Testata:
PARASITE IMMUNOLOGY
fascicolo: 2, volume: 23, anno: 2001,
pagine: 103 - 108
SICI:
0141-9838(200102)23:2<103:IRTMAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL EPITOPES; SYNTHETIC PEPTIDES; IMMUNOGENICITY; VACCINE; INDUCTION; SEQUENCES; MAP;
Keywords:
malaria; T-cell epitope; B-cell epitope; multiple antigen peptides; circumsporozoite protein; HLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Avila, SLM Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Ave Dr Eneas de CarvalhoAguiar 500, BR-05403140 Sao Paulo, Brazil Univ Sao Paulo Ave Dr Eneas de Carvalho Aguiar 500 Sao Paulo Brazil BR-05403140 BC
Citazione:
S.L.M. Avila et al., "Immune responses to multiple antigen peptides containing T and B epitopes from Plasmodium falciparum circumsporozoite protein of Brazilian individuals naturally exposed to malaria", PARASITE IM, 23(2), 2001, pp. 103-108

Abstract

We have evaluated the immune responses of individuals living in a malaria endemic area of Brazil to the (T1B)(4), a multiple antigen peptide (MAP) from Plasmodium falciparum circumsporozoite (CS) protein and the related monoepitope MAPs, B-4 and (T1)(4), and the linear peptides, T1B and B. The highest antibody frequencies were against MAPs containing the B cell epitope sequence (T1B)(4) (42.2%) and B-4 (28.8%), while the highest lymphoproliferative response frequencies were against the MAPs containing the T cell epitope sequence (T1)(4) (47%) and (T1B)(4) (36.4%). We analysed individual responses considering lymphoproliferative response to (T1)(4) MAP and IgG antibody titre to (T1B)(4) as patterns of ideal cellular and humoral responses, respectively The frequency of responders, cellular and/or humoral was 66.6%,significantly higher than non responders (P = 0.003). We also determined the HLA class II haplotype of each individual bur no association between these and immune response patterns to the MAPs was observed. The results showed that individuals primed against P. falciparum in their natural habitat, present a very diverse array of responses against the same peptide antigens,varying from no response in one-third of the individuals to cognate B and T cell responses. Our study underlines the importance of previous studies of vaccine candidates to guarantee that the immunization will be capable of reverting inefficient or absent responses to malaria epitopes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:26:35