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Titolo:
A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy
Autore:
Dai, Y; Iwata, K; Kondo, E; Morimoto, T; Noguchi, K;
Indirizzi:
Hyogo Coll Med, Dept Anat & Neurosci, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Osaka Univ, Fac Dent, Dept Oral Physiol, Suita, Osaka 5650871, Japan OsakaUniv Suita Osaka Japan 5650871 Physiol, Suita, Osaka 5650871, Japan
Titolo Testata:
PAIN
fascicolo: 3, volume: 90, anno: 2001,
pagine: 287 - 296
SICI:
0304-3959(20010215)90:3<287:ASIIFE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE INJURY; NMDA ANTAGONIST TREATMENT; AFFERENT SENSORY NEURONS; CHRONIC NEUROPATHIC PAIN; C-FOS; SCIATIC-NERVE; NOXIOUS-STIMULATION; RESPONSE PROPERTIES; NUCLEUS NEURONS; CORD NEURONS;
Keywords:
Fos protein; hyperalgesia; neuropathic pain; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Noguchi, K Hyogo Coll Med, Dept Anat & Neurosci, 1-1 Mukogawa Cho, Nishinomiya, Hyogo6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya HyogoJapan 6638501
Citazione:
Y. Dai et al., "A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy", PAIN, 90(3), 2001, pp. 287-296

Abstract

In order to clarify the central mechanisms of thermal hyperalgesia produced by peripheral nerve injury, Fos protein-like immunoreactive (Fos-LI) cells in spinal dorsal horn neurons were studied in rats with chronic constriction nerve injury (CCI) following graded thermal stimulation of the hind paw. The graded thermal stimuli (cold: 5, 10 and 15 degreesC, heat. 42, 46 and54 degreesC) were applied to the planter surface of the operated hind paw I 14 days after CCI or sham operation, and the number of Fos-LI cells in the spinal dorsal horn was quantified. Many Fos-LI cells were expressed in the superficial laminae of the spinal dorsal horn both in sham-operated and CCI rats following thermal stimulation. Fos-LI cells were mainly restricted to the medial half of the superficial laminae of the spinal dorsal horn, and were sparsely distributed in the deeper laminae. The number of Fos-LI cells in the superficial laminae (laminae I-II) of the dorsal horn was significantly higher in CCI rats after stimulation at 10 and 46 degreesC, but not at the other stimulating temperatures (5, 15, 42, and 53 degreesC) as compared to that in sham-operated rats. In laminae III-IV, the number of Fos-LI cells was significantly higher at all stimulus temperatures in CCI rats when compared to the sham-operated rats. No distribution difference of Fos-LI cells was observed between CCI and sham-operated rats in laminae V-VI. Thus, in the spinal dorsal horn of the CCI rats, there was a selective increasein thermal stimulus-induced Fos-LI cells in the superficial dorsal horn after stimulating at near noxious threshold intensities and a non-selective increase in Fos-LI cells in laminae III-IV after both noxious and innocuous thermal stimuli. The increase of Fos-LI cells in the superficial laminae may be related to hypersensitivity to noxious stimuli while the increase of Fos-LI cells in laminae III-IV may be related to an increased sensitivity toboth noxious and innocuous stimuli that le;lds to increased reflex activity following nerve injury. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:31:38