Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents
Autore:
Flynn, BL; Verdier-Pinard, P; Hamel, E;
Indirizzi:
Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 rra, ACT 0200, Australia NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Screening Technol Branch, Frederick, MD 21702 USA NCI Frederick MD USA 21702 eening Technol Branch, Frederick, MD 21702 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 5, volume: 3, anno: 2001,
pagine: 651 - 654
SICI:
1523-7060(20010308)3:5<651:ANPCAT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR MODULATORS; CELL ACTIVATION INHIBITOR; HALOCYCLIZATION REACTIONS; UNSATURATED SULFIDES; COMBRETASTATIN; DERIVATIVES; POTENT; ANTIESTROGENS; THIOPHENES; CI-959;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Flynn, BL Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 200, Australia
Citazione:
B.L. Flynn et al., "A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents", ORG LETT, 3(5), 2001, pp. 651-654

Abstract

[GRAPHICS]Flexible, convergent access to 2,3-disubstituted benzo[b]thiophenes has been developed. The most concise approach involves sequential coupling of o-bromoiodobenzenes with benzylmercaptan and zinc acetylides to give benzyl o-ethynylphenyl sulfides which react with iodine to give 3-iodobenzo[b]thiophenes in a 5-endo-dig iodocyclization. These iodides can be further elaborated using palladium-mediated coupling and/or metalation techniques. This method has been applied to the synthesis of some novel tubulin binding agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:44:26